The goal of this observational study is to learn about survival and prognostic factors in patients who underwent surgical treatment for primary squamous cell carcinoma of the nasal vestibule. The main questions it aims to answer are: * what is the prognosis of patients affected by squamous cell carcinoma of the nasal vestibule? * are there any specific factors that could influence prognosis? * is it possible to elaborate a new staging system, able to overcome the limitations of the currently used ones? Data about patients, tumour and type of surgery performed will be collected. Participants will be followed-up for a minimum 6 months period after surgery.
This study will address the survival of patients with squamous cell carcinoma of the nasal vestibule (NV-SCC), and it will analyze factors influencing it. In particular, apart from demographic features of the patient, data regarding the origin of the tumour and its extension will be collected and the lesion will be restaged according the the three classification systems used at present (Wang's classification, AJCC for nasal cavity cancers, AJCC for non-melanomatous skin cancer of head and neck region), given the current controversy regarding the best staging system. Furthermore data related to the surgery and the final histology will be collected. All collected data will be analyzed in order to investigate any possible factor related to overall survival, disease specific survival and disease free survival. Patients will be followed for a minimum of 6 months up to 5 years after surgery.
Study Type
OBSERVATIONAL
Enrollment
300
Surgery will be performed according to extension of the tumour, i.e. local resection limited to the vestibule, partial rhinectomy, total rhinectomy, extended total rhinectomy
Centre Hospitalier Universitaire de Toulouse
Toulouse, Touluse, France
RECRUITINGHumanitas Research Hospital
Rozzano, Milan, Italy
RECRUITINGCagliari University Hospital
Cagliari, Italy
RECRUITINGIRCCS San Raffaele Hospital
Milan, Italy
RECRUITINGVarese University Hospital
Varese, Italy
RECRUITINGSheffield Teaching Hospital NHS Foundation Trust
Sheffield, United Kingdom
RECRUITINGSurvival
Overall Survival
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Survival
Disease Free Survival
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Survival
Disease Specific Survival
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
Gender
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
Age
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
Site of origin of the tumour
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
Subsites involved by the tumour
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
cT stage (according to TNM nasal cavities, Wang classification, TNM skin)
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
cN stage
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
pT stage (according to TNM nasal cavities, Wang classification, TNM skin)
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
pN stage (according to TNM nasal cavities, Wang classification, TNM skin)
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
Grade
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
Dimensions
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
Depth of infiltration
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
Perineural invasion
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
Perivascular invasion
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
Surgical margin status
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
Surgical procedure
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Factors influencing survival (demographics, tumour-related, surgery-related)
Adjuvant treatment
Time frame: From time of enrollment to event (death, recurrence) up to 60 months.
Davide Di Santo, MD
CONTACT
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