Study of Potential CYP3A4 Induction by INDV-2000 in Healthy Adults

Inclusion Criteria: 1. Participant must be 18 to 55 years of age inclusive, at the time of signing the informed consent. 2. Body weight of a minimum of 50.0 kg at the screening visit and body mass index within the range 18.0 - 32.0 kg/m\^2 (inclusive). 3. Male or female who is healthy as determined by medical evaluation. 4. Females will be of non-childbearing potential. Females of non-childbearing potential are considered women who: * Do not have a uterus, or * Are surgically sterile (eg, has undergone complete hysterectomy, bilateral oophorectomy, hysteroscopic sterilization, or tubal ligation), or * Have permanent cessation of ovarian function due to ovarian failure or surgical removal of the ovaries, or * Are post-menopausal as defined by 12 months or more of spontaneous amenorrhea as confirmed by a follicle-stimulating hormone (FSH) \> 30 mIU/mL 5. Male participants agree to follow contraception guidelines specified in the Protocol. 6. Continuous non-smoker who has not used nicotine- and tobacco-containing products for at least 3 months prior to the first dosing based on participant self-reporting. 7. Capable of giving signed informed consent. Exclusion Criteria: 1. Have an ongoing medical history of clinically significant neurological, cardiovascular, renal, hepatic, chronic respiratory or gastrointestinal (GI) disease, psychiatric or other disorder as judged by an Investigator that could potentially affect the study outcomes or compromise participant safety. 2. Have clinically significant abnormal biochemistry, hematology or urinalysis results as judged by an Investigator. 3. Have a history of narcolepsy or sleep apnea. 4. Have disorders that may interfere with drug absorption, distribution, metabolism and excretion processes. 5. Current active hepatic or biliary disease. 6. Participants with cholecystectomy \< 90 days prior to screening. 7. Positive test results for human immunodeficiency virus (HIV)-1/HIV-2 antibodies, Hepatitis B surface antigen (HBsAg) or Hepatitis C antibodies. 8. Have a blood pressure reading outside of the following range: Systolic \< 86 or \> 149 mmHg; Diastolic \< 50 or \> 94 mmHg 9. Serious cardiac illness or other medical condition including, but not limited to: * Uncontrolled arrhythmias * History of congestive heart failure * QTcF \> 450 msec for males and \> 470 msec for females or history of prolonged QT syndrome * Myocardial infarction * Uncontrolled symptomatic angina 10. History of suicidal ideation within 30 days prior to providing written informed consent as evidenced by answering "yes' to questions 4 or 5 on the suicidal ideation portion of the C-SSRS completed at the screening visit or history of a suicide attempt (per the C-SSRS) in the 6 months prior to informed consent. 11. Healthy participants who are taking, or have taken, any prescribed or over-the-counter drugs (other than 2 grams of acetaminophen per 24-hour period as of Day 1, hormone replacement therapy, or thyroid hormone replacement therapy) or herbal remedies in the 14 days or 5 half-lives (whichever is longer) prior to first dose of study drug. 12. Treatment with any known drugs that are moderate or strong inhibitors/inducers of CYP3A4 or CYP2C19, including St. John's Wort, within 30 days prior to first dose of study drug. 13. Any consumption of food or drink containing poppy seeds, grapefruit or Seville oranges within 14 days prior to the first dose of study drug. 14. Regular alcohol consumption in males \> 21 units per week and females \> 14 units per week (1 unit = ½ pint beer, 25 mL of 40% spirit or a 125 mL glass of wine). 15. Positive test result for alcohol and/or drugs of abuse at screening or at check-in. 16. Female participant with a positive pregnancy test at the screening visit or at first check-in or who are lactating. 17. Concurrent treatment or treatment with an investigational drug or device within 30 days or 5 half-lives (whichever is longer) prior to the first dose of study drug. 18. Blood donation of approximately 500 mL or more within 56 days or plasma donation within 7 days of screening. 19. Known hypersensitivity to INDV-2000 or any other ingredient in the INDV-2000 formulation. 20. Known hypersensitivity to midazolam or any other ingredient in midazolam HCl syrup. 21. Site staff and/or participants who have a financial interest in, or an immediate family member of either the site staff and/or Indivior employees, directly involved in the study. 22. Major surgical procedure (as defined by the Investigator) within 90 days prior to the first dose of study drug or still recovering from prior surgery. 23. Concurrent enrollment in another clinical study, unless it is an observational study. 24. Participants who are unable, in the opinion of the Investigator, to comply fully with the study requirements. 25. Any condition that, in the opinion of the Investigator or Indivior, would interfere with evaluation of the study drug or interpretation of participant safety or study results.