The Purpose of This Study is to Evaluate the Effects of Ruxolitinib Cream on Adults With Atopic Dermatitis Experiencing Sleep Disturbance.

Inclusion Criteria: * Has clinically confirmed diagnosis of active AD according to Hanifin and Rajka (1980) criteria. * Has at least a 2-year history of AD (information obtained from medical chart, participant's physician, or directly from the participant). * Has an overall BSA affected by AD of 3%-20% (excluding scalp) at the screening and baseline visits. * Has an IGA score ≥ 2 at the screening and baseline visits. * Has an Itch NRS score ≥ 4 at the screening and baseline visits. * Willing to complete the once-daily Itch NRS (24-hour recall period) entries at approximately the same time each day during the study. * Agrees to maintain a regular sleep schedule during the study period. * Willing and able to follow required study procedures for measuring sleep for the duration of the study. Exclusion Criteria: * Currently using a wearable or other device for monitoring sleep patterns and unwilling to discontinue its use during the study. * Currently has a schedule that includes nighttime work shifts. * Has had significant flares or unstable course in AD (ie, condition worsened significantly or required significant change in medications, as per medical judgment) in the previous 4 weeks before screening (information obtained from medical chart, participant's physician, or directly from the participant). * Has received any ultraviolet B phototherapy (including tanning beds) or excimer laser within 4 weeks prior to the screening period. * Has had psoralen plus ultraviolet A treatment within 4 weeks prior to the screening period. * Has received a nonbiological investigational product or device within 4 weeks prior to the screening period, or is currently enrolled in another investigational drug study. * Has received treatment with JAK inhibitors (systemic or topical) within 4 weeks prior to the screening period. * Has had prior treatment with a JAK inhibitor that was discontinued for safety reasons or tolerance problems. * Has a known or suspected allergy to ruxolitinib or any component of the study drug.