The goal of this clinical trial is to study whether the products with nicotinamide fortified could improve skin whitening in 30 to 50-year-old women. Partipants will be randomly assigned to two study groups and use products (study product plus nicotinamide supplement and placebo product without nicotinamide supplement) for 2 months, twice a day. Researchers will compare the two groups whether there are significant improvement in skin whitening via skin measurement and analysis systems.
This study is two arms, randomized, double-blind controlled trial. 70 eligible partipants at two study sites will be enrolled and use randomly assigned products (study product plus nicotinamide supplement and placebo product) for 2 months. Participants will visit the study site for three times on baseline day, day 30, and day 60, all relevant data will be captured, measured via professional skin equipment system and recorded in the data management system. At the end of study, the explantory and statisitcal analysis will be conducted to validate the assumption that the using products with nicotinamide fortified could improve skin whitening in 30 to 50-year-old women.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
70
Participants in this arm will use a bottle of 25ml each time, twice a day, for 2 months.
Participants in this arm will use a bottle of 25ml each time, twice a day, for 2 months.
Ai'er Hospital
Shanghai, Shanghai Municipality, China
SPRIM Central Lab
Shanghai, Shanghai Municipality, China
Skin Brightness
The changes of the skin brightness by Spectrophotometer CM2600D
Time frame: baseline day 0, day 30, day 60
Skin Barrier
The changes of skin barrier in terms of TEWL (Trans Epidermal Water Loss) via Aquaflux F200
Time frame: baseline day 0, day 30, day 60
Skin Hydration
The changes of skin hydration by Corneometer CM 825
Time frame: baseline day 0, day 30, day 60
Skin Gloss
The changes of skin gloss by Glossmeter
Time frame: baseline day 0, day 30, day 60
Skin Radiance Scale
The changes of skin radiance scale (0-9) assessed in three aspects (Radiant Lumimous,Shallowness, and Dullness) by professionals
Time frame: baseline day 0, day 30, day 60
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