Aim of the clinical monocentric study is to assess the resistance training exercise intervention in patients with Heart Failure with reduced Ejection Fraction (HFrEF) and coronary artery disease that will best improve peak oxygen uptake (Peak Vo2) and leg strength (assessed Isokinetic). The investigators hypothesize that resistance training exercise with induced a high stress metabolic is more important exercise with induced than a lower stress metabolic.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
112
3/7 Resistance Training Method
3X9 Resistance Training Method
Erasme Hospital
Brussels, Belgium
Change in Peak VO2 after 3 months
Change in Peak oxygen consumption (VO2) after three 3 months intervention
Time frame: Baseline and 3 months
Change in strength knee extensor after 3 months
Change in strength knee extensor (60°/sec) after three months intervention
Time frame: Baseline and 3 months
Change in VE/VCO2 slope after 3 months
Change in ventilatory efficiency (VE/VCO2) slope at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in submaximal exercise capacity after 3 months
Submaximal exercise capacity will be measured using watts at the first ventilatory threshold (VT1)
Time frame: Baseline and 3 months
Change in workload maximal after 3 months
Change in workload max at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in Body fat after 3 months
Change in Body fat at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in lean mass after 3 months
Change in lean mass at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in leg lean mass after 3 months
Change in leg lean mass at baseline and 3 months intervention
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Time frame: Baseline and 3 months
Change in bone mass after 3 months
Change in bone mass at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in Visceral adipose tissue after 3 months
Change in Visceral adipose tissue measure by Dual-energy X- ray absorptiometry (DEXA) at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in hand grip force after 3 months
Change in hand grip force on non dominant hand at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in ventilation metaboreflex function after 3 months
Change in ventilation during metaboreflex test at baseline and 3 months intervention (Briefly, the subject is asked to exercise with the non-dominant arm by performing two 5 min handgrip manoeu- vres reaching approximately 50% of pre-determined maximal con- traction, in random order, separated by a 30 min interval: one bout with circulatory occlusion during the last 10 s of exercise and the all 3 min recovery phase ('clamp session'). During the clamp session, forearm cuff inflation to 30 mmHg above systolic blood pressure from the last 10 s of exercise till the end of the 3 min recovery phase; after cuff inflation, the subject is instructed to relax. Ergore- ceptor sensitivity is quantified as the percentage of the ventilatory and haemodynamic response to exercise maintained by circulatory occlusion during the third minute compared with the third minute of basal recovery.)
Time frame: Baseline and 3 months
Change in diastolic blood pressure metaboreflex function after 3 months
Change in diastolic blood pressure during metaboreflex test at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in heart rate at rest after 3 months
Change in heart rate at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in resting heart rate variability at rest after 3 months
Change in resting heart rate variability at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change 30 s sit-to-stand after 3 months
Change 30 s sit-to-stand at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in isometric strength knee extensor after 3 months
Change in strength knee extensor (isometric) at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in 120°/sec strength knee extensor after 3 months
Change in strength knee extensor (120°/sec) at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in 180°/sec strength knee extensor after 3 months
Change in strength knee extensor (180°/sec) at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change strength knee extensor in leg extension after 3 months
Change in one repetition maximal in leg extensor machine at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in sub maximal strength knee extensor in leg extension after 3 months
Change in 10 repetitions maximal in leg extensor machine at baseline and 3 months intervention
Time frame: Baseline and 3 months
Change in heart rate recovery after 3 months
Change in heart rate recovery at baseline and 3 months intervention
Time frame: Baseline and 3 months