The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
50
We will measure arterial stiffness using arterial tonometry.
We will collect limited ultrasound images of the heart.
We will perform ultrasound imaging of the carotid artery.
Mayo Clinic Rochester
Rochester, Minnesota, United States
RECRUITINGArterial thickness
Measured by carotid ultrasound intimal media thickness reporting in mm
Time frame: Baseline
Arterial stiffness
Measured by carotid ultrasound pulse wave velocity reporting in m/s
Time frame: Baseline
Baroreflex sensitivity
The slope between heart rate and blood pressure at rest and during the Valsalva Maneuver (ms/mmHg)
Time frame: Baseline
Sympathetic response to stress
Blood pressure or muscle sympathetic nerve activity response to sympathoexcitatory stressors (mm/Hg or bursts/min).
Time frame: Baseline
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
We will measure the elastic properties of the arteries using elastography.
We will measure the ankle-brachial index to assess peripheral artery blood flow.
We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.