Bioavailability Study of Folate in Healthy Subjects

Inclusion Criteria: * Body Mass Index (BMI) ≥18 and ≤25Kg/m², * For women: menopausal without hormone replacement therapy (HRT) or with HRT started from more than 3 months or non-menopausal with a negative blood pregnancy test and using reliable contraception since at least 3 cycles before the beginning of the study and agreeing to keep it during the entire duration of the study, * Good general and mental health within the opinion of the investigator: no clinically significant and relevant abnormalities of medical history or physical examination, * Able and willing to participate to the study by complying with the protocol procedures as evidenced by his/her dated and signed informed consent form, * Affiliated with a social security scheme, * Agree to be registered on the subjects in biomedical research file. After V1 biological analysis the subjects will be eligible to the study on the following criteria: \- Adequate folate status (serum folate between 10 and 45nmol/L, erythrocyte (RBC) folate between 405 and 952 nmol/L), Exclusion Criteria: * Suffering from a metabolic disorder, * Suffering from a severe chronic disease found to be inconsistent with the conduct of the study by the investigator, * Suffering from diseases that could potentially interfere with folate absorption or metabolism, * With a known or suspected food allergy or intolerance or hypersensitivity to any of the study products' ingredient, * With a low venous capital of blood samples according to the investigator's opinion, * Pregnant or was pregnant less than 6 months prior to the study, or lactating women or intending to become pregnant within 3 months ahead, * Under treatment or regular use of treatment or dietary supplement which could significantly affect folate status or other study parameter(s), * Use of supplements containing folate (i.e. folic acid, 5-MTHF) the last 3 months, * With significant change in lifestyle, food habits, physical activity or medications in the 3 months before the V1 visit or not agreeing to keep them unchanged throughout the study, * With a current or planned in the next 3 months' specific diet (hyper or hypocaloric, vegan, vegetarian…) or stopped less than 3 months before the study, * With a personal history of anorexia nervosa, bulimia or significant eating disorders according to the investigator, * Consuming more than 2 standard drinks of alcoholic beverage daily for men and women or not agreeing to keep his alcohol consumption habits unchanged throughout the study. * Smoking, * Having a lifestyle deemed incompatible with the study according to the investigator including high level physical activity, * Taking part in another clinical trial or being in the exclusion period of a previous clinical trial, * Having received, during the last 12 months, indemnities for clinical trial higher or equal to 4500 Euros, * Under legal protection (guardianship, wardship) or deprived from his rights following administrative or judicial decision, * Presenting a psychological or linguistic incapability to sign the informed consent, * Impossible to contact in case of emergency. * Who made a blood donation in the 3 months before the V0 visit or intending to make it within 3 months ahead. After V1 biological analysis the subjects will be non-eligible to the study on the following criteria: * Presence of anemia (hemoglobin\<12g/dL in women and 13g/dL in men), * Vitamin B12 levels (serum cobalamin \<148pmol/L), * Serum total homocysteine levels≥15µmol/L, * Serum creatinine \>0,96mg/dL for women and \>1,21mg/dL for men, * Control record (Glycaemia, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, GGT, ASAT, ALAT, Urea and CBC) with clinically significant abnormality according to the investigator.