This project aims to compare the effect of preoperative administration of melatonin and gabapentin in reducing preoperative anxiety, stress markers and postoperative pain levels in trauma patients undergoing surgery. Gabapentin has analgesic as well as sedative properties. Melatonin, a hormone has been extensively used in intensive care units and has found to improve the sleep cycle and reduce pain. It is now being explored as a preoperative medication.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
70
melatonin will be administered orally preoperatively as premedication
melatonin will be administered orally preoperatively as premedication
Aiims
New Delhi, National Capital Territory of Delhi, India
RECRUITINGpreoperative anxiety
evaluate the difference in the preoperative anxiety score(Numerical Rating Scale ) before and after drug administration
Time frame: 30 minutes after drug administration
inflammatory markers
o The serum cortisol and IL6 levels (biochemical markers of stress) intraoperatively and postoperatively
Time frame: before and 30 minutes after drug administrartion
Sedation score
Sedation score based on Observer Assessment of Alertness/Sedation Scale (OAA/S) before and after drug administration
Time frame: before and 30 minutes after drug administrartion
post operative analgesia
o Total fentanyl consumption 24 hours post-surgery
Time frame: 24 hours postoperative
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