Impact of High Mechanical Index Ultrasound Impulses on Left Ventricular Stroke Volume With Intravenous Microbubbles

University of Nebraska

Overview

This study will investigate whether applying high mechanical index (MI) impulses from a diagnostic ultrasound transducer when using ultrasound enhancing agent (UEA) microbubble infusion will result in subclinical improvement in left ventricle systolic function.

The purpose of this study is to investigate whether applying high MI impulses from a diagnostic ultrasound transducer when using ultrasound enhancing agent(UEA) microbubble infusion will result in subclinical improvement in LV systolic function detected by left ventricular outflow tract velocity time integral (LVOT VTI).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Conditions

Cardiac Disease

Interventions

high MI impulsesDIAGNOSTIC_TEST

patients will receive intermittent high MI impulses(\>1.0) in addition to low MI imaging. LVOT VTI will be measured at different times per protocol.

low MI impulsesDIAGNOSTIC_TEST

patients will receive low MI imaging only. LVOT VTI will be measured at different times per protocol.

Eligibility

Sex: ALLMin age: 19 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: age 19 years or older Exclusion Criteria: 1. severe aortic valve stenosis 2. pregnant or lactating women 3. atrial fibrillation 4. very poor image quality despite contrast use. 5. unstable cardiac condition such as cardiogenic shock. 6. allergy to UEA 7. presence of right to left or bidirectional shunts. 8. Patients on mechanical circulatory support.

Outcomes

Primary Outcomes

Left Ventricle Outflow Tract (LVOT) First Ventilatory Threshold VTI

Time frame: 10 minutes

Secondary Outcomes

stroke volume

The volume of blood pumped out of the left ventricle of the heart during each systolic cardiac contraction

Time frame: 10 minutes

Data from ClinicalTrials.gov

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