Prevalence of Cardiac Amyloidosis in Patients Undergoing Surgery for Lumbar Spinal Stenosis.

Steen Hvitfeldt Poulsen200 enrolled

Overview

Patients undergoing surgery for lumbar spinal stenosis will have biopsies of the ligamentum flavum sent to the department of pathology for histologic screening. If the ligament biopsy contains amyloid, patients will receive an echocardiogram, an ecg, biomarker testing, and a bone tracer scintigraphy diagnostic of cardiac amyloidosis.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

200

Conditions

Cardiac Amyloidosis Spinal Stenosis

Interventions

DPD scintigraphyDIAGNOSTIC_TEST

Bone tracer scintigraphy, diagnostic for transthyretin cardiac amyloidsis

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Scheduled for surgery for lumbar spinal stenosis * Age \> 65 years * Informed written consent Exclusion Criteria: * Known amyloidosis * Myelomatosis * Monoclonal gammopathy of unknown significance, MGUS * Morbus Waldenstrøm

Locations (1)

Department of Cardiology, Aarhus University Hospital

Aarhus N, Denmark

RECRUITING

Outcomes

Primary Outcomes

Diagnosis of cardiac amyloidosis

DPD scintigraphy with a Perugini Grade 2 og higher.

Time frame: 1 year

Central Contacts

Bertil Ladefoged

CONTACT

40927245 berlad@rm.dk

Data from ClinicalTrials.gov

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