Motivational Behavioral and Functional MRI Impairment in Patients With Chronic Neuropathic Pain

Fondation Ophtalmologique Adolphe de Rothschild50 enrolled

Overview

The main hypothesis of this study is that the alteration of the reward circuitry underlying the motivational deficit in chronic pain patients compared to healthy subjects results in a decrease in the capacity for reward learning. The fMRI studies have shown that this type of learning depends on the dopaminergic system innervating key regions of the reward system.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Pain

Interventions

reward learning taskOTHER

during usual follow-up patients will complete a remard learning task questionnaire. This questionnaire cannot be assimilated to a clinical intervention.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * For cases: patients managed in the neurosurgery department or at CETD for chronic neuropathic pain, of central or peripheral origin. * For controls: matched to a case on age (±5 years) and sex Exclusion Criteria: * Neurodegenerative or inflammatory neurological pathology * Clinical depressive syndrome * High doses of opioid treatment (greater than 100 mg/day of morphine equivalent) * Impaired judgment or inability to receive information that does not allow the performance of behavioral tasks * Absolute contraindication to MRI (e.g. pacemaker, implantable pacemaker, metallic intra-orbital foreign body)

Locations (1)

Hôpital Fondation Adolphe de Rothschild

Paris, France

RECRUITING

Outcomes

Primary Outcomes

To compare reward learning ability in patients with chronic neuropathic pain compared with an age (±5 years) and gender-matched control population

the reward learning ability will be assessed using a specific task. The result of the task questionnaire is a numeric score.

Time frame: Day 0

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.