Evaluation of Bone Metabolism Biomarkers in Periodontal Diseases

Necmettin Erbakan University60 enrolled

Overview

This study evaluates the levels of biomarkers associated with bone metabolism in patients with different periodontal conditions.

Background: In this study, the levels of bone metabolism markers found in the saliva of individuals with different periodontal conditions were compared and the relationship of these markers with periodontal status was examined. Method: A total of 60 individuals, 20 with periodontitis (P), 20 with gingivitis (G), and 20 with periodontal healthy (S), were included in the study. Periodontal clinical parameters (plaque index, gingival index, bleeding on probing, clinical attachment level and probing pocket depth) and saliva samples were obtained from the individuals. Bone metabolism biomarker (necrotizing factor (TNF)-α, osteoprotegerin (OPG), nuclear factor kappa-β receptor activator ligand (RANKL) and sclerostin) levels in saliva samples were evaluated by enzyme-linked immunosorbent assay (ELISA).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Periodontal Diseases

Interventions

ELISADIAGNOSTIC_TEST

ELISA(enzyme-linked immunosorbent assay)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18-65 years old. * not having any systemic disease that may affect periodontal status * not smoking and alcohol use * volunteer to participate in the study Exclusion Criteria: * periapical pathologies; * resulting from orthodontics and occlusion extreme forces, including mechanical forces; * chronic high-dose steroid therapy; * radiation or immunosuppressive therapy; * pregnancy; * breastfeeding; * allergy or sensitivity to any medication. * Periodontal therapy or drug therapy for at least 6 months of study participants

Locations (1)

Necmettin Erbakan University

Konya, Turkey (Türkiye)

Outcomes

Primary Outcomes

Evaluation of bone metabolism biomarkers in different periodontal conditions

The levels of bone metabolism markers in the saliva of individuals with different periodontal status were compared and the relationship of these markers with periodontal status was examined.

Time frame: baseline

Secondary Outcomes

Probing pocket depth

Probing pocket depth(PPD) was measured for determining the severity of the disease and clinical outcome. High probing depth shows more severe periodontal disease.

Time frame: baseline

Gingival index

The differences in gingival index scores between periodontally healthy and periodontitis.The gingival index was recorded for determining and classifying gingival status. The gingival index (Gİ) scores each site on a 0 being normal and 3 being severe inflammation characterized by edema, redness, swelling and spontaneous bleeding.

Time frame: baseline

Plaque index

The differences in plaque index scores between periodontally healthy and periodontitis. Plaque index (PI) was recorded for determining and classifying oral hygiene status. The plaque index (PI) scores each site on a with 0 being no plaque in gingival area and 3 abundance of soft matter within the gingival pocket and/or on the gingival margin and adjacent tooth surface.

Time frame: baseline

Data from ClinicalTrials.gov

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