Constitution of a biobank of tissues, whole blood and plasma samples and stools to identify markers associated with treatment response, postoperative morbidity including neuro-cognitive and mood complications and prognosis of Inflammatory Bowel disease or colorectal cancer.
Inflammatory Bowel disease (Crohn, Ulcerative colitis) and colorectal cancer are frequent affections and the microbiota plays a major role in their physiopathology involving the immune system. In this setting, the interplay between gut microbiota and brain is still unexplored. To evaluate the interaction of the microbiota and the immune system with the host in these two chronic diseases, we aim to create a prospective biobank. A small amount of tissue will be taken during surgery. A whole blood, plasma and stoll samples will also be taken from the patient. All samples will be anonymized.
Study Type
OBSERVATIONAL
Enrollment
500
Service de Chirurgie Viscérale - Hôpital Saint Antoine
Paris, France
RECRUITINGRelation between biological parameters and outcomes of digestive disease (IBD, CRC)
identify relations between serumon response to treatment, postoperative outcomes including neuro-cognitive and mood complications and prognosis.
Time frame: up to 12 months after the incusion
Relation between biological parameters and outcomes of digestive disease (IBD, CRC)
identify relations between plasma on response to treatment, postoperative outcomes including neuro-cognitive and mood complications and prognosis.
Time frame: up to 12 months after the incusion
Relation between biological parameters and outcomes of digestive disease (IBD, CRC)
identify relations between DNA on response to treatment, postoperative outcomes including neuro-cognitive and mood complications and prognosis.
Time frame: up to 12 months after the incusion
Relation between biological parameters and outcomes of digestive disease (IBD, CRC)
identify relations between faeces) on response to treatment, postoperative outcomes including neuro-cognitive and mood complications and prognosis.
Time frame: up to 12 months after the incusion
Exploratory study on the physiopathology of host-microbiota interactions to determinate the occurrence of intestinal and extra-intestinal complications
genetic polymorphisms, serum markers, intestinal microbiota markers to determining the occurrence of intestinal and extra-intestinal complications
Time frame: up to two months after the incusion
Exploratory study on the physiopathology of host-microbiota interactions to determinate the response to treatments
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genetic polymorphisms, serum markers, intestinal microbiota markers determining : response to treatments
Time frame: up to two months after the incusion
Exploratory study on the physiopathology of host-microbiota interactions
genetic polymorphisms, serum markers, intestinal microbiota markers determining : interactions between host and microbiota
Time frame: up to two months after the incusion
Brain-microbiota interaction
Exploring the pathophysiology of host-microbiota interactions in postoperative cognitive or behavioral changes involving inflammation pathways
Time frame: up to two months after the incusion