Aminophylline Infusion on Pain Intensity After Ureterocopic Lithotripsy

Tanta University50 enrolled

Overview

This study will be conducted to evaluate the effect of intraoperative systemic aminophylline infusion on pain intensity in patients undergoing ureteroscopic lithotripsy surgeries with ureteric stent placement at the end of the procedure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Aminophylline Pain Ureterocopic Lithotripsy

Interventions

Aminophylline groupDRUG

Patients will receive 4 mg/kg aminophylline diluted in 100 ml normal saline over 20 minutes after induction of anesthesia and positioning of patients in lithotomy position.

Control groupOTHER

Patients will receive 100 ml normal saline over 20 minutes after induction and lithotomy positioning.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Aged between 18 to 50 years * American society of anesthesiology (ASA) physical status I - II * Body mass index (BMI) less than 30.0 kg/m2 * Scheduled for ureteroscopic lithotripsy surgery with D-J ureteric stent placement at the end of procedure * Under general anesthesia. Exclusion Criteria: 1. Patients with central nervous system diseases, cardiovascular diseases, arrhythmias, cerebrovascular diseases, convulsions, renal impairment or hepatic dysfunction. 2. Pregnancy or lactation. 3. Patients with a history of allergy to aminophylline. 4. Coffee consumption (more than 2 cups/day) 5. Patients with opioid addiction or patients treated with B agonists, tranquilizers, or antidepressants. 6. Short procedures less than 30 minutes or procedures not requiring D-J stent placement.

Locations (1)

Tanta University Hospitals

Tanta, ElGharbiaa, Egypt

Outcomes

Primary Outcomes

Intensity of pain

Visual analogue score (VAS) score: will be measured on arrival to PACU, at 30 minutes, 1 hour, 2 hour, 6, 12 and 24 hour after surgery.

Time frame: In post anesthesia care unit (PACU)

Secondary Outcomes

Intensity of pain

Visual analogue score (VAS) score: will be measured on arrival to PACU, at 30 minutes, 1 hour, 2 hour, 6, 12 and 24 hour after surgery.

Time frame: 24 hour after surgery

Total amount of opioid dose

If Patients reported VAS score more than 3, they will receive intravenous 0.5 mg /kg pethidine. All patients will be observed in PACU for at least 2 hour and in the ward on the day of surgery for confirming any side effects or complications.

Time frame: 24 hour after surgery

The incidence of postoperative adverse reactions

the incidence of adverse reactions, such as arrhythmia, postoperative nausea and vomiting (PONV) and postoperative lightheadedness will be recorded in both groups.

Time frame: 24 hour after surgery

Data from ClinicalTrials.gov

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