The study will test and compare the efficacy of a single essential amino acid valine with a combination of essential amino acids (EAA) supplement on fatigue, frailty, and cognitive function in end-stage kidney disease (ESKD) patients undergoing hemodialysis (HD) treatment.
This single center outpatient study will test and compare the efficacy of a single essential amino acid, valine with a combination of essential amino acids (EAA) supplementation on fatigue, fragility and cognitive function in end-stage kidney disease (ESKD) patients aged 18-64 years undergoing hemodialysis (HD) treatment at least three times a week.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
28
The University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States
RECRUITINGBrief Fatigue Inventory (BFI) score
Changes in global fatigue score measured with the 9-item Brief Fatigue Inventory (BFI). The first 3 questions assess fatigue severity, and the remaining 6 questions measure the impact of fatigue on activity, mood, walking, work, relationships, and enjoyment of life. Respondents rate each item on a 0-10 numeric scale, with 0 meaning "no fatigue" and 10 meaning "fatigue as bad as you can imagine." Scores of all 9 items yield global fatigue burden. A lower average global fatigue score indicates milder fatigue and a higher score severe fatigue.
Time frame: Baseline to 17 weeks
Handgrip strength test
Change in handgrip strength measured by a dynamometer in lbs
Time frame: Baseline to 17 weeks
Trail Making Test (TMT)
Change in minutes to complete Trail Making Test (TMT) A and B
Time frame: Baseline to 17 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.