The purpose of this study was to investigate the effect of pitavastatin or pitavastatin and ezetimibe combination therapy on glucose metabolism compared to atorvastatin in patients with atherosclerotic cardiovascular disease with metabolic syndrome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
250
Pitavastatin 4 mg will be given.
Pitvastatin 4 mg plus ezetemibe 10 mg will be given.
Atorvastatin 40 mg will be given.
Yonsei University Health System, Severance Hospital
Seoul, South Korea
RECRUITINGChange form baseline homeostatic model assessment for insulin resistance (HOMA-IR) at 24 weeks
Changes of homeostatic model assessment for insulin resistance (HOMA-IR) form baseline to 24 weeks will be compared among the three groups.
Time frame: At 24 weeks
Proportion of fasting glucose ≥100 mg/dL
Time frame: At 24 weeks
Proportion of HbA1C ≥6.5%
Time frame: At 24 weeks
Proportion of new-onset diabetes mellitus
Time frame: At 24 weeks
Changes of HOMA-β at 24 weeks
Time frame: At 24 weeks
Changes of fasting glucose at 24 weeks
Time frame: At 24 weeks
Changes of insulin at 24 weeks
Time frame: At 24 weeks
Changes of HbA1c at 24 weeks
Time frame: At 24 weeks
Changes of triglyceride at 24 weeks
Time frame: At 24 weeks
LDL-cholesterol change at 24 weeks
Time frame: At 24 weeks
HDL-cholesterol change at 24 weeks
Time frame: At 24 weeks
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