Active Breaks in People With Type 1 Diabetes

Liverpool John Moores University118 enrolled

Overview

the investigators aim to determine the effect of 4 weeks of frequent active breaks from prolonged sitting on time in target glycaemic range in people with type 1 diabetes with high habitual sedentary behaviour.

An open-label randomised controlled trial, whereby participants will complete pre-randomisation baseline procedures before allocation to 4wks of habitual activity (control) or active breaks. Interstitial glucose concentrations (fGM), insulin dose and physical activity/ postural transitions (ActivPAL) will be monitored throughout. To improve generalisability and feasibility of recruiting the required number of participants, the study will be completed in a free-living environment using remote data collection methods.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

118

Conditions

Type 1 Diabetes

Interventions

Active BreaksBEHAVIORAL

Participants will be asked to interrupt sitting with 3 min bouts of walking every 30 min from 9am-5pm

Eligibility

Sex: ALLMin age: 18 YearsMax age: 66 Years

Medical Language ↔ Plain English

Inclusion Criteria: * T1D diagnosis more than 3 years ago * Sedentary (\> 10h per waking day sedentary (sitting or lying) * Using insulin therapy with multiple daily injections or insulin pump * Aged 18-66 (UK retirement age) * Use of Abbot FreeStyle Libre 2 fGM (\>6 weeks to avoid potential lifestyle changes as a result of sensor use) Exclusion Criteria: * Engaged in structured planned exercise (e.g. running, cycling, gym, or sports) * Pregnancy or planning to become pregnant * \<6 months postpartum or stopped breastfeeding \<1 month before recruitment * Existing cerebrovascular or cardiovascular disease * Significant history of hyperglycaemia (HbA1c \>85 mmol/mol) * History of severe hypoglycaemia requiring third party assistance within the last 3 months

Locations (1)

Liverpool John Moores University

Liverpool, United Kingdom

RECRUITING

Outcomes

Primary Outcomes

Change in time in target glycaemic range

flash glucose monitoring

Time frame: change from baseline to final week of the intervention

Secondary Outcomes

Change in glycaemic variability (coefficient of variation)

flash glucose monitoring

Time frame: change from baseline to final week of the intervention

Change in insulin dose

Insulin dose

Time frame: change from baseline to final week of the intervention

Change in Concentration of Hba1c

HbA1c