To evaluate the effect of ciprofol anesthesia Induction on hemodynamics in elderly patients undergoing elective noncardiac surgery，a prospective, randomized, controlled trial.
90 elderly patients undergoing noncardiac surgery were randomly divided into propofol group and ciprofol group, who were given propofol 1 \~ 2mg/kg or ciprofol 0.2-0.5mg/kg during anesthesia induction respectively. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and BIS values at various time points during anesthesia induction were collected. At the same time, rates of injection pain, muscle fasciculation, arrhythmia, cough and perioperative hepatic and renal functions were compared between the two groups. The primary outcomes were the fluctuations in hemodynamic parameters during induction. The secondary outcome were adverse reactions, BIS values and changes of hepatic and renal functions during induction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
90
Propofol 1-2mg / kg was for anesthesia induction. Propofol is a hypnotic agent that is used as an induction agent and as a maintenance anaesthetic delivered by continuous i.v. infusion or intermittent i.v. bolus.
Ciprofol 0.2～0.5mg/kg was for anesthesia induction. Ciprofol is an intravenous sedative-hypnotic and a short-acting GABAA receptor agonist. It activates GABAergic neurons by enhancing chloride ion influx. It is used for anesthetic induction and maintenance agents include rapid induction of general anesthesia, rapid return of consciousness, minimal residual effects on the central nervous system and less injection pain.
Hemodynamic changes：Systolic blood pressure (SBP)
Systolic blood pressure (SBP) during anesthesia induction
Time frame: From the beginning of drug administration to 30 minutes after intubation
Hemodynamic changes: Diastolic blood pressure(DBP)
Diastolic blood pressure(DBP) during anesthesia induction
Time frame: From the beginning of drug administration to 30 minutes after intubation
Hemodynamic changes: Heart rate （HR ）
Heart rate （HR ）during anesthesia induction
Time frame: From the beginning of drug administration to 30 minutes after intubation
adverse reactions: injection pain
injection pain from propofol or ciprofol intravenous injection
Time frame: anesthesia induction
adverse reactions: muscle fasciculation
muscle fasciculation induced by propofol or ciprofol intravenous induction
Time frame: anesthesia induction
adverse reactions：arrhythmia
arrhythmia induced by propofol or ciprofol intravenous induction
Time frame: anesthesia induction
perioperative hepatic function: Aspartate Aminotransferase ( AST)
level of Aspartate Aminotransferase ( AST)
Time frame: Before surgery , 1day after operation
perioperative hepatic function: Alanine Aminotransferase ( ALT)
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level of Alanine Aminotransferase ( ALT)
Time frame: Before surgery , 1day after operation
perioperative renal function: creatine
level of creatine
Time frame: Before surgery , 1day after operation
perioperative renal function:Blood Urea Nitrogen
level of Blood Urea Nitrogen（BUN)
Time frame: Before surgery , 1day after operation
Monitoring Depth of Anesthesia
BIS values
Time frame: anesthesia induction