Lung and Diaphragm Ultrasound Evaluation During Weaning From Mechanical Ventilation in COVID-19 Patients

Second Affiliated Hospital, School of Medicine, Zhejiang University35 enrolled

Overview

The goal of this observational study is to learn about the function of lung and diaphragm ultrasound during weaning from mechanical ventilation in COVID-19 patients. The aim of this study was that the lung ultrasound score and diaphragm muscle mobility could be a potential predictive factor of weaning success.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Weaning COVID-19 Lung Ultrasound Diaphragm Ultrasound

Interventions

Point-of-Care UltrasoundOTHER

Ultrasonographic scans of the lung and right hemidiaphragm were acquired after 30 min from the beginning of the SBT, or immediately before reconnecting the patient to the ventilator in the case of SBT failure occurring before

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age \> 18 years, * critically ill patients with COVID-19 (defined as those requiring mechanical ventilation due to respiratory failure), and eligible for their first SBT according to the attending physician's judgement that the underlying disease which led to intubation had sufficiently resolved. Exclusion Criteria: * patients with previous cardiothoracic surgery or pleurodesis and patients who presented with stridor (due to upper airway involvement) as a cause of extubation failure * neuromuscular disease

Locations (1)

The Second Affiliated Hospital of Zhejiang University anesthesiology department

Hangzhou, Zhejiang, China

Outcomes

Primary Outcomes

The primary end-point was to verify the lung and diaphragm ultrasound evaluation if the predicts weaning success/failure from mechanical ventilation

Weaning failure was defined as failure to pass the spontaneous-breathing trial or the need for re-intubation within 48 h following extubation

Time frame: spontaneous-breathing trial started until 48 hours following extubation

Secondary Outcomes

The secondary outcome was to verify the predictive value of the traditional weaning parameters

Weaning failure was defined as failure to pass the spontaneous-breathing trial or the need for re-intubation within 48 h following extubation

Time frame: spontaneous-breathing trial started until 48 hours following extubation

Data from ClinicalTrials.gov

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