The main purpose of this study is to investigate the effects of switching from glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy to tirzepatide glucose-dependent insulinotropic polypeptide (GIP) GLP-1 RA agonist in participants with type 2 diabetes (T2D).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
152
Administered SC
Change From Baseline in Hemoglobin A1c (HbA1c)
HbA1c is the glycosylated fraction of hemoglobin A. HbA1c is measured to identify average plasma glucose concentration over prolonged periods of time.
Time frame: Baseline, Week 12
Change From Baseline in Percentage of Time Per Day That Continuous Glucose Monitoring (CGM)-Derived Values Were >180 Milligram/Deciliter (mg/dl) (10 Millimole/Liter (mmol/L))
Change from Baseline in Percentage of Time per Day that CGM-derived Values were \>180 mg/dl (10 mmol/L) was assessed.
Time frame: Baseline, Week 4
Change From Baseline in Percentage of Time Per Day That CGM-derived Values Were >180 mg/dl (10 mmol/L)
Change from Baseline in Percentage of Time per Day that CGM-derived Values were \>180 mg/dl (10 mmol/L) was assessed.
Time frame: Baseline, Week 12
Change From Baseline in Duration of Time in Minutes Per Day That CGM Derived Values Were >180 mg/dl (10 mmol/L)
Change from Baseline in Duration of Time in Minutes per Day that CGM derived Values were \>180 mg/dl (10 mmol/L) was assessed.
Time frame: Baseline, Week 4
Change From Baseline in Duration of Time in Minutes Per Day That CGM Derived Values Were >180 mg/dl (10 mmol/L)
Change from Baseline in Duration of Time in Minutes per Day that CGM derived Values were \>180 mg/dl (10 mmol/L) was assessed.
Time frame: Baseline, Week 12
Change From Baseline in Fasting Serum Glucose (FSG)
Change from Baseline in FSG was assessed.
Time frame: Baseline, Week 12
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Fiel Family and Sports Medicine PC
Tempe, Arizona, United States
New Hope Research Development
Corona, California, United States
Velocity Clinical Research, Gardena
Gardena, California, United States
Velocity Clinical Research, Huntington Park
Huntington Park, California, United States
Velocity Clinical Research, Huntington Park
Los Angeles, California, United States
Valley Clinical Trials, Inc.
Northridge, California, United States
Dream Team Clinical Research
Pomona, California, United States
Scripps Whittier Diabetes Institute
San Diego, California, United States
Metabolic Institute of America
Tarzana, California, United States
CMR of Greater New Haven, LLC
Waterbury, Connecticut, United States
...and 22 more locations
Change From Baseline in Weight
Change from Baseline in Weight was assessed.
Time frame: Baseline, Week 12