Micro- and Macro-Circulation in Cardiac Surgery Patients

IRCCS Policlinico S. Donato100 enrolled

Overview

The hypothesis under the study is that there could be a link between a dysfunction in peripheral microcirculation, sublingual microcirculation or cardiovascular control and the development of post cardiac surgery major morbidities (stroke, acute kidney injury, prolonged intubation, mediastinitis, surgical reopening, death). The state of sublingual microcirculation, of peripheral microcirculation and cardiovascular control will be assessed in 100 patients undergoing cardiac surgery during general anesthesia before the intervention and at the end of the intervention at the arrival in post-surgery ICU by means of signal processing techniques. The extracted markers will be used to assess a statistical prediction model of major morbidities.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Cardiac Surgery Coronary Artery Bypass Graft Surgical Aortic Valve Replacement

Interventions

ECG, arterial pressure and peripheral flow velocity via a percutaneous laser doppler will be acquired together with images of the sublingual microcirculation detected with sidestream darkfield images microscope

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age \>18 yrs * indication for a cardiac surgery intervention * spontaneous sinus rhythm * informed consent Exclusion Criteria: * know autonomic nervous systems pathologies or dysfunctions * pregnancy

Outcomes

Primary Outcomes

Prediction of major morbidities by means of the variability of cardiovascular and hemodynamics markers

Statistical model assessment; time series variability analysis

Time frame: 24 months