Effect of Regional Versus General Anesthesia on Thirty-day Outcomes Following Carotid Endarterectomy: a Matched-pairs Cohort Study.

University of Virginia37,204 enrolled

Overview

The goal of this observational study is to assess the effect of regional versus general anesthesia on carotid endarterectomy thirty-day outcomes. The main questions it aims to answer are: * Is regional anesthesia associated with lower incidence of major morbidity and mortality? * Is regional anesthesia associated with lower incidences of secondary adverse events? Participants will be sampled from the 2015-2019 American College of Surgeons National Surgical Quality Improvement Program

Study Type

OBSERVATIONAL

Enrollment

37,204

Conditions

Regional Anesthesia Morbidity Carotid Artery Diseases Perioperative/Postoperative Complications

Interventions

Anesthetic technique (regional versus general)

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Elective, non-emergent cases * Regional anesthesia * General anesthesia Exclusion Criteria: * Concurrency in procedures * Acute kidney injury (preoperative) * End-stage renal disease (preoperative) * Metastatic disease (preoperative) * Wound infection (preoperative) * Sepsis (preoperative) * ASA 5

Outcomes

Primary Outcomes

Major morbidity and mortality

Stoke, myocardial infarction, or death

Time frame: Thirty days

Secondary Outcomes

Minor morbidity

Reintubation, prolonged (\>48 hour) ventilator dependence, pneumonia, deep venous thrombosis, pulmonary embolism, superficial surgical site infection (SSI), deep incisional SSI, organ space SSI, wound dehiscence, sepsis, septic shock, acute kidney injury, and progressive renal insufficiency

Time frame: Thirty days

Bleeding events

Requiring transfusion

Time frame: Thirty days

Unplanned resource utilization

Unplanned readmission and unplanned reoperation

Time frame: Thirty days

Mortality

Time frame: Thirty days