The Effect of Intradermal Acupuncture on Gallbladder Meridian Points on Cerebral Hemodynamics in Relevant Brain Regions for Major Depressive Disorder Based on fNIRS Technology

Inclusion Criteria: Inclusion criteria for control group: 1. Healthy control participants who could provide a recent depression screening report, and confirm they have not any cardiovascular, respiratory, digestive, urinary, hematological, endocrine, or neurological disease; 2. 15 ≤ age ≤22 years, male or female; 3. Participants have clear consciousness and could communicate with others normally; 4. Participants could understand the full study protocol and have high adherence. Written informed consent is signed by adult participants themselves，and the minor participants is signed by a guardian; 5. Participants should be right-handed; Inclusion criteria for observation group: 1. MDD patients should meet the diagnostic criteria of the International Classification of Diseases 11th Edition (ICD-11) diagnostic criteria for MDD; 2. 15≤ age ≤22, male or female; 3. Participants have clear consciousness and could communicate with others normally; 4. Participants could understand the full study protocol and have high adherence. Written informed consent is signed by adult participants themselves，and the minor participants is signed by a guardian; 5. Not taking antidepressants or antipsychotic drugs for at least 4 weeks before enrollment; 6. Participants should be right-handed; Exclusion Criteria: Exclusion criteria for control group: 1. Participants with serious primary diseases of cardiovascular diseases, liver diseases, kidney diseases, urinary diseases, and hematological diseases; 2. Participants have an illness, alcohol dependence, or a history of drug abuse; 3. Pregnant or lactating participants; 4. Participants with intellectual disabilities who can't cooperate with the questionnaire survey; 5. Participants with bleeding tendency, skin disease, allergic constitution, and allergic to adhesive tape; 6. The test site of participants has scars, hyperpigmentation, red and swollen; 7. Participants are participating in other trials; Exclusion criteria for observation group: 1. Participants with serious primary diseases of cardiovascular, respiratory, digestive, urinary, hematological, endocrine, neurological disease, and other serious primary diseases, and the disease cannot be effectively controlled clinically; 2. MDD caused by organic mental disorders, schizophrenia, bipolar disorder, psychoactive substances, and non-addictive substances; 3. Participants with suicidal tendencies; 4. Pregnant or lactating participants; 5. Participants with intellectual disabilities who cannot cooperate with the questionnaire survey; 6. Participants with bleeding tendency, skin disease, allergic constitution, and allergic to adhesive tape; 7. The skin at the test site of participants has scars, hyperpigmentation, red and swollen; 8. Participants are participating in other trials;