This study attempts to compare safety and long-term oncological outcomes between laparoscopic surgery and open surgery in the treatment of clinical T4b Colorectal cancer.
Laparoscopic surgery is controversial for patients with T4b colorectal cancer who require multivisceral resection. With the expansion of the indications for laparoscopic surgery in recent years, surgeons try to perform laparoscopic multivisceral resection for the treatment of clinical T4b colorectal cancer. In this study, investigators attempted to compare safety and long-term oncological outcomes between laparoscopic surgery and open surgery in the treatment of clinical T4b colorectal cancer. This study was a multicenter retrospective cohort study based on a multicenter database which contained hospitalization. According to the operation method, the patients were divided into laparoscopic multivisceral resection group(patients who underwent laparoscopic surgery or conversion to open surgery) and open multivisceral resection group(patients who underwent open surgery directly). The short-term and long-term result was compared between groups.
Study Type
OBSERVATIONAL
Enrollment
638
The laparoscopic approach was used for the treatment of clinical T4b colorectal cancer
Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China
Blood loss
Blood loss is defined as intraoperative blood loss and measured in milliliters(ml).
Time frame: Until the end of the operation, an average of 8 hours.
Complications
Complications are defined as all surgery-related adverse events postoperatively, such as anastomotic leak, infection, which are measured in frequency.
Time frame: Until the patient recovered and was discharged from the hospital, an average of 10 days.
Hospital stay after surgery
Hospital stay after surgery is defined as the length of time from the end of surgery to the discharge of patient, which is measured in days.
Time frame: Until the patient recovered and was discharged from the hospital, an average of 10 days.
Overall survival
Overall survival is defined as the time from the surgery to death or last follow-up, regardless of disease recurrence, which was measured in months.
Time frame: The endpoint of the overall survival assessment is the last follow-up or patient death. Follow-up time is up to 72 months.
Disease-free survival
Disease-free survival is defined as the time from the surgery to disease recurrence or last follow-up, which was measured in months.
Time frame: The endpoint of the disease-free survival assessment is the last follow-up or disease recurrence. Follow-up time is up to 72 months.
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