This is a two-arm randomized parallel study. Patients who will be meeting the above-mentioned criteria and agree to take part in the study, were asked to sign an informed consent prior conducting the study. The whole study protocol were presented to the local institutional review board (IRB).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
80
Metformin 500 mg twice
Faculty of Pharmacy, Cairo University
Cairo, Egypt
Kasr El Aini Hospital
Cairo, Egypt
Kasr El-Aini Hospital
Cairo, Egypt
Postprocedural myocardial injury
the occurrence of postprocedural myocardial injury, defined as a postprocedural elevation of CKMB or cTnI more than 1 times the 99 th percentile of the URL \[ 24 hours post PCI\]
Time frame: 6 months
CK-MB
Mean peak values of CK-MB after intervention
Time frame: 24 hours post PCI
cTn
Mean peak values of cTnI after intervention
Time frame: 24 hours post PCI
LVEF in percent
Echo: to measure LVEF in percent
Time frame: Baseline- 6 months
LVMI in g/m2
left ventricular mass index (LVMI) will be calculated in g/m2 using the sex and body surface area (m²) and measures of LVEDD in mm, IVSd in mm, PWd from the measures in the echocardiography
Time frame: Baseline- 6 months
GFR
glomerular filtration rate (GFR) will be calculated (unit ml/min) using age in years, sex, body weight in kilograms and serum creatinine in mg/dL
Time frame: Baseline- monthly- 6 months
Serum creatinine (SCr)
Serum creatinine (SCr) in mg/dL
Time frame: Baseline- monthly- 6 months
Lactate concentration
lactate concentration unit in mmol/L
Time frame: Baseline - 6 months
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Glucometabolic State
Glucometabolic State using HbA1c (unit mmols/mol)
Time frame: Baseline - 6 months
Incidence of Cardiovascular Event
Cardiovascular events including major cardiac adverse events (MACE; death, recurrent MI, target lesion revascularization), stroke, non-elective hospitalizations for chest pain or heart failure, all recurrent coronary interventions, and internal cardiac defibrillator implantations. Mortality will be divided into cardiac and non- cardiac. Cardiac death will be divided into three categories: heart failure, sudden death, and others.
Time frame: Baseline - 6 months
Rate of hospitalization
The number of hospitalizations within each group will be calculated during the study period.
Time frame: through study completion, an average of 6 months