Stroke survivors frequently suffer disabilities including motor and cognitive problems, impairments in speech and vision, depression, and several other disabilities that worsen their quality of life. Some will recover fully after stroke and others will have permanent impairments. Few studies show trajectories of recovery in different domains after stroke, hence recovery time-lines are not fully known. Also, the whole range of mechanisms leading to recovery are not precisely known (1). To monitor those mechanisms one can utilize biomarkers. In parallel to the studies of recovery, studies on time series of biomarkers after stroke are limited (2). Hence, a crucial first step to increase knowledge on biomarkers of stroke recovery is to gain a better understanding of the time course of both stroke recovery and biomarker patterns. Biomarkers can later be used for outcome predictions after stroke.
BACKGROUND Stroke survivors frequently suffer disabilities including motor and cognitive problems, impairments in speech and vision, depression, and several other disabilities that worsen their quality of life. Some will recover fully after stroke and others will have permanent impairements. Few studies show trajectories of recovery in different domains after stroke, hence recovery time-lines are not fully known. Also, the whole range of mechanisms leading to recovery are not precisely known (1). To monitor those mechanisms one can utilize biomarkers. In parallel to the studies of recovery, studies on time series of biomarkers after stroke are limited (2). Hence, a crucial first step to increase knowledge on biomarkers of stroke recovery is to gain a better understanding of the time course of both stroke recovery and biomarker patterns. Biomarkers can later be used for outcome predictions after stroke. WORK PLAN AIM Determine temporal profiles describing the speed, order, and degree of recovery in neurological and cognitive functions in various domains with simultaneous profiling of changes in blood biomarker concentrations, in the acute, subacute phases and long-term of stroke. Determine individual and interindividual variations in recovery in the different domains. Informed consent Written informed consent will be obtained from all willing participants or their next-of-kin.
Study Type
OBSERVATIONAL
Enrollment
600
All stroke patients are included.
Department of Neurology, Department of Neurorehabilitation and Department of Clinical Genetics, Sahlgrenska University Hospital
Gothenburg, Sweden
RECRUITINGMedical data Clinical data
Stroke subtype, medical history, life style questions between baseline and follow-ups
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years.
Stroke severity
Change of National Institutes of Health Stroke Scale (NIHSS) between baseline and follow-ups.
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years.
Functional independence
Change of modified Ranking Scale (mRS) functional independence
Time frame: Pre-stroke estimation, baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years.
Walking ability
Change in functional Ambulation Category between baseline and follow ups.
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years.
Postural control
Change in postural control, evaluated by Berg Balance Scale (BBS), between baseline and follow ups.
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years.
Blood samples
Analyses of plasma protein levels and circulating RNA profiles in comparison to baseline
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years
FMA-arm test
Change in performance on Fugl-Meyer Assessment of Motor Recovery after Stroke test between baseline and follow-up.
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years
SAFE
Change in performance on Shoulder Abduction and Finger Extension (SAFE) score between baseline and follow ups.
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years
MoCA
Change in the Montreal Cognitive Assessment between baseline and follow ups.
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years
Neuroimaging
Changes in MRI scans between baseline and follow-ups.
Time frame: Baseline, and change from baseline at 3, and 12 months; 2 years
D-FIS
Change in the Daily Fatigue Impact Scale (D-FIS) between baseline and follow ups.
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years
HAD
Change in the Hospital Anxiety and Depression (HAD) scale between baseline and follow ups.
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years
SIS
Change in domains of Stroke Impact Scale (SIS) between baseline and follow ups.
Time frame: Baseline, and change from baseline and 3, 6 and 12 months; 2 and 5 years
FAS
Change in the Verbal Fluency Test between baseline and follow ups.
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years
CWT
Change in the Color-Word Interference test between baseline and follow ups.
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years
TMT
Change in the Trail Making Test between baseline and follow ups.
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years
RBANS
Change in the 10-word test from Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) between baseline and follow ups.
Time frame: Baseline, and change from baseline at 3, 6 and 12 months; 2 and 5 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.