A Clinical Trial of KVA12123 Treatment Alone and in Combination With Pembrolizumab In Advanced Solid Tumors (VISTA-101)

Inclusion Criteria 1. Willing and able to provide informed consent. 2. Be at least 18 years of age at the time of consent. 3. Has histologically or cytologically confirmed, locally advanced or metastatic solid tumor that has progressed or was non-responsive to standard of care therapy and for which no available curative therapy exists. 4. Has expected survival ≥16 weeks. 5. Presence of measurable disease by iRECIST. 6. Has an ECOG performance status score of 0 or 1. 7. Has adequate organ function within 10 days prior to the start of study treatment. 8. Has normal thyroid function or hypothyroid with stable supplementation. 9. Has consented to the collection of archival tissue prior to study treatment initiation. 10. Participants with prior exposure to systemic anticancer therapy including investigational agents following a 4-week washout period are eligible. Participants with prior small molecule targeted therapy or other short half-life drugs are eligible following a 2-week washout period. 11. Participants having prior curative radiation therapy completed 2 weeks prior to study drug administration or prior palliative radiation therapy to non-CNS disease completed at least 1 week prior to study drug administration are eligible. 12. HIV-infected participants must be on anti-retroviral therapy (ART) and have a well-controlled HIV infection/disease. 13. Participants with a history of HBV infection having durable HBsAg loss and undetectable serum HBV DNA no longer requiring treatment are eligible. 14. Participants with history of HCV infection are eligible if HCV viral load is undetectable at screening and participants have completed curative antiviral therapy. 15. Post-menopausal women and surgically sterile men and women are permitted. 16. Patients of childbearing potential are permitted to participate under the following conditions: 1. Must have negative urine pregnancy test result within 72 hrs prior to the first dose of any study drug 2. Must agree not to become pregnant during the study and for 120 days after the final dose of any study drug 3. Must agree not to breastfeed or donate ova, starting at time of informed consent and continuing through 120 days after the final dose of any study drug 4. If sexually active in a way that could lead to pregnancy, must consistently use 2 acceptable methods of birth control (contraception), at least 1 of which must be highly effective starting at time of informed consent and continuing throughout the study and for 120 days after the final dose of any study drug. 17. Patients who can father children are permitted to participate under the following conditions: 1. Must agree not to donate sperm starting at the time of informed consent and continuing throughout the study period and for 120 days after the final dose of any study drug 2. If sexually active with a person of childbearing potential in a way that could lead to pregnancy, must consistently use 2 acceptable methods of birth control (contraception), at least 1 of which must be highly effective starting at the time of informed consent and continuing throughout the study and for 120 days after the final dose of any study drug 3. If sexually active with a person who is pregnant or breastfeeding, must consistently use a condom starting at time of informed consent and continuing throughout the study and for 120 days after the final dose of any study drug. 18. Must be willing and able to comply with the trial procedures and the follow-up schedule. Exclusion Criteria 1. Untreated CNS metastatic disease, leptomeningeal disease, or cord compression. 2. Concurrent cancer other than disease under study requiring systemic treatment. Participants with basal cell or squamous cell skin cancer treated with curative intent, carcinoma in-situ of the cervix or breast treated with curative intent, RAI stage 0 Chronic Lymphocytic Leukemia, monoclonal gammopathy of undetermined significance, superficial bladder cancer or very low and low risk prostate cancer (localized Gleason score ≤ 6) under active surveillance are eligible. 3. Has a known additional malignancy that is progressing or has required active treatment within the past 3 years. 4. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg QD of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior the first dose of study drug. 5. History of (non-infectious) pneumonitis/interstitial lung disease (ILD) that required steroids or current pneumonitis/ILD. 6. Prior treatment with VISTA-targeted therapy. 7. Prior history of allogeneic, solid organ or stem cell transplant, or adoptive T-cell transplant. 8. Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g., CTLA-4, LAG-3, OX 40, CD137), and was discontinued from that treatment due to a Grade 3 or higher immune-related adverse event (irAE). 9. Active known or suspected autoimmune disease that has required systemic treatment within the past year. Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment. 10. Prior systemic anticancer therapy, including investigational agents, within 4 weeks of treatment. Participants with prior small molecule targeted therapy or other short half-life drugs are eligible following a 2-week washout period. 11. Has received prior radiation therapy within 2 weeks of start of study treatment or has a history of radiation pneumonitis. 12. Has received radiation therapy to the lung that is \>30 Gy within 6 months of the first dose of study treatment. 13. Has received a live or live-attenuated vaccine within 30 days prior to the first dose of study intervention. 14. Any requirement for daily supplemental oxygen. 15. Any condition requiring systemic treatment with corticosteroids (\>10 mg QD prednisone equivalents) or other immunosuppressive medications within 14 days before the first dose of study drug. 16. Serious or poorly controlled cardiovascular disease. 17. Chronic hepatitis B or C. 18. HIV-infected participants with a history of Kaposi sarcoma and/or Multicentric Castleman Disease. 19. Has an active infection requiring systemic therapy. 20. Known active or latent tuberculosis. 21. If the participant had major surgery, must have recovered adequately from the procedure and/or any complications. 22. Toxicities arising from prior cancer therapy that have not resolved to Grade 1 or baseline. 23. Red blood cell or platelet infusion within the preceding 2 weeks. 24. Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment. 25. Known hypersensitivity to any excipient contained in the drug formulation of KVA12123. 26. Any significant history of drug allergy as assessed by the investigator. 27. Positive urine pregnancy test within 72 hrs of study drug administration. 28. Participants who are breastfeeding, pregnant, or planning to become pregnant from time of informed consent until at least 120 days after final dose of study drug. 29. Has a history or current evidence of any condition, therapy, or laboratory abnormality, or other circumstance that might confound the results of the study or interfere with the participant's participation for the full duration of the study. 30. Has a known psychiatric or substance abuse disorder that would interfere with the participant's ability to cooperate with the requirements of the study. 31. Inability to comply with study procedures.