Cortical Processes During Walking Post-stroke

University of Florida30 enrolled

Overview

The study aims to use novel mobile imaging techniques with high-density electroencephalography (EEG) to quantify cortical processes synchronized to the biomechanics of walking. Here, the study has two aims - the primary aim is to quantify the cortical processes that contribute to gait dysfunction early post-stroke, and the second aim is to determine how cortical processes are mediated by mechanical assistance during early gait training post-stroke. Participants will wear an electroencephalography (EEG) cap to measure brain activity and other non-invasive physiological sensors. Participants will be asked to perform different tasks, such as walking at different speeds and walking with different levels of body weight support.

This study will recruit 15 subacute post-stroke individuals and 15 age-matched neurotypical individuals between the age of 18-80 years old.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Stroke, Acute Walking, Difficulty

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for post-stroke patients: * Participants will have a unilateral brain lesion within six months prior to participation in this project; * Paresis confined to one side; * Ability to walk for 10 meters continuously; * Absence of severe cognitive dysfunction as demonstrated by a Mini-Mental score greater than 24; * Absence of severe concurrent medical problems; * Ability to provide informed consent. Exclusion Criteria for age-matched adults: * Any major neurological, cardiovascular, orthopedic, and psychiatric diagnoses

Outcomes

Primary Outcomes

Brain activity during walking measured by EEG

Changes in brain activity during walking with different levels of weight support

Time frame: through study study completion, an average of 2 years