The aim of this study is to investigate the effects of Xanthohumol on resting energy expenditure and substrate oxidation in healthy women. It is assumed that resting energy expenditure and fatty acid oxidation is higher after Xanthohumol ingestion.
In a crossover design, 16 healthy young women ingest 172 mg micellar solubilized Xanthohumol or placebo in a randomized fashion. During an observational period of 3 hours, the acute effects of Xanthohumol on the resting energy expenditure and substrate oxidation is determined by respiratory gas analysis. An additional 30-minute determination of the resting energy expenditure and substrate oxidation is executed 24 hours after Xanthohumol ingestion. The wash-out period will be 28 days.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
16
single administration of 4 soft gelatine capsules each containing 43 mg micellar solubilized Xanthohumol
single administration of 4 soft gelatine capsules containing only micelles
University of Bonn
Bonn, Germany
Acute Effect on Resting Energy Expenditure
calculated from Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min, given in kcal/24 hours
Time frame: assessed uninterrupted for 3 hours post dose
Prolonged Effect on Resting Energy Expenditure
calculated from Volume of inhaled oxygen (VO2) in L/min and exhaled carbon dioxide (VCO2) in L/min, given in kcal/24hours
Time frame: assessed uninterrupted for 30 minutes 24 h post dose
Acute Effect on Substrate Oxidation
assessed by the respiratory quotient (RQ=VCO2/VO2), given in percent
Time frame: assessed uninterrupted for 3 hours post dose
Prolonged Effect on Substrate Oxidation
assessed by the respiratory quotient (RQ=VCO2/VO2), given in percent
Time frame: assessed uninterrupted for 30 minutes 24 h post dose
Acute Effect on Blood pressure
given in millimeter mercury
Time frame: 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 minutes post dose
Prolonged Effect on Blood pressure
given in millimeter mercury
Time frame: 24 hours, 24 hours and 10 minutes, 24 hours and 20 minutes, 24 hours and 30 minutes post dose
Acute Effect on Pulse
given in beats per minute
Time frame: 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160, 170, 180 minutes post dose
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Prolonged Effect on Pulse
given in beats per minute
Time frame: 24 hours, 24 hours and 10 minutes, 24 hours and 20 minutes, 24 hours and 30 minutes post dose