Outcomes After PCI of the Aneurysmatic Right Coronary Artery

San Luigi Gonzaga Hospital90 enrolled

Overview

This study aims to evaluate procedural and clinical outcomes of acute coronay syndrome (ACS) patients with aneurysmatic culprit right coronary artery (RCA).

The investigators sought differences in procedural (slow-flow, no-reflow, distal embolisation,Thrombolysis in Myocardial Infarction final flow (TIMI) etc.) and in immediate and long-term clinical outcomes between several subgroups such as index vs staged percutaneous coronary intervention (PCI), premedication vs none, use of IIb/IIIa inhibitors vs none, bare metal stent (BMS) vs drug eluting stent (DES), ultrathin DES vs thick DES, durable polymer vs bioresorbable or free polymer etc. The investigators also want to investigate the efficacy of different technical manoeuvres involved in resolving high thrombotic burden before stent deployment, such as thrombus aspiration, dilatation, intracoronary infusion of adenosine or thrombolytic agents, direct stenting etc.). Long-term follow-up includes target vessel failure (Cardiac Death, target vessel MI, clinically-driven target vessel revascularisation), define or probable stent thrombosis, target vessel revascularisation for ACS, clinically driven target vessel revascularisation and intrastent restenosis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Coronary Disease Coronary Artery Ectasia Right Coronary Artery Occlusion Right Coronary Artery Stenosis STEMI

Interventions

Percutaneous Coronary InterventionPROCEDURE

Treatment of coronary stenoses with a drug-eluting stent or balloon

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with ACS of the aneurysmatic or ectasic RCA * Patient with at least 6 months clinical or angiographic follow-up * Patients with accurate procedural and clinical records (particularly use of drugs before, during and after procedure, according to RCA PCI procedure (index or staged). Exclusion Criteria: * Elective aneurysmatic or ectasic RCA PCI * Patient with lack of accurate procedural and clinical data * Patient with lack of clinical or angiographic follow up

Locations (8)

Ospedale Papa Giovanni XXIII

Bergamo, Italy

RECRUITING

Azienda Ospedaliera Brotzu

Cagliari, Italy

RECRUITING

Policlinico Universitario G.Rodolico

Catania, Italy

Outcomes

Primary Outcomes

Technical success

Defined as final TIMI flow \> 3 (TIMI 0: absence of any integrate flow beyond the coronary occlusion; TIMI 1: faint antegrade flow beyond the coronary occlusion with incomplete filling of the distal coronary bed; TIMI 2: delayed flow beyond the coronary occlusion with complete filling of the distal coronary bed; TIMI 3: normal flow with complete filling of the distal coronary bed)

Time frame: Procedural (from the start to the end of the procedure)

Secondary Outcomes

Target Lesion Failure

Combination of cardiac death, target vessel MI and clinically target lesion revascularization

Time frame: 12 moths

Central Contacts

Giulio Piedimonte, MD

CONTACT

+393201764900 giulio.piedimonte@gmail.com

Enrico Cerrato, MD

CONTACT

+393479317104 enrico.cerrato@gmail.com

Data from ClinicalTrials.gov

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