Effects of Beef Consumption on Skeletal Muscle Protein Homeostasis and Inflammatory Factors in Pre- and Postmenopausal Females

University of Arkansas65 enrolled

Overview

This will be a randomized study to determine if animal-based protein-rich food sources can stimulate greater muscle protein turnover and whole-body protein balance and reduce skeletal muscle inflammatory markers in postmenopausal women compared to vegetarian base protein-rich foods.

A randomized cross-sectional controlled trial will be conducted to quantify whole-body and muscle protein turnover and skeletal muscle inflammation following 5-days of consumption of either beef or isonitrogenous plant-based sources of protein in normal/overweight and obese post-menopausal females. A premenopausal normal/overweight group consuming beef containing study meals will also be recruited to serve as a healthy control comparison.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Menopause Related Conditions

Interventions

meals consisting of primarily animal protein sourcesOTHER

an omnivorous diet

meals consisting of plant protein sourcesOTHER

an herbivorous diet

Eligibility

Sex: FEMALEMin age: 35 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Postmenopausal women ages 50-65 (absence of menstruation for at least 12 months). 2. Premenopausal women ages 35-45 (presence of normal monthly menstruation for the past 12 months). 3. BMI of 20.0 - 34.9 kg/m2. 4. COVID-19 negative and/or asymptomatic Exclusion Criteria: 1. Any substantial musculoskeletal injuries/diseases that have limited daily activities in the past month. 2. Unable to stop the use of anti-inflammatory drugs for the week prior to and during study. 3. Diagnosed metabolic or hormonal disease (i.e., renal, cardiovascular, thyroid, polycystic ovary syndrome, or type I/II diabetes mellitus). 4. Currently pregnant. 5. Gave birth or was lactating within previous 12 months. 6. Undergone gastric bypass/bariatric surgery. 7. Clinically significant weight gain or loss (\>5% change) in the last 12 months. 8. Consuming metabolism-altering drugs or medications (i.e., corticosteroids, stimulants, insulin, thyroid medication). 9. Unable or unwilling to suspend anti-clotting medications including aspirin use for 5 days prior to Visit 4. 10. Participating in \>200 minutes/week of vigorous exercise and/or \>4 days/week of resistance training. 11. Unwilling to fast overnight. 12. Surgical menopause. 13. Having undergone hormone replacement therapy in the last 12 months.

Locations (1)

Center of Translational Research in Aging and Longevity

Little Rock, Arkansas, United States

Outcomes

Primary Outcomes

Net change in muscle protein synthesis (% per day).

Change in net muscle protein synthesis between groups.

Time frame: Study meals are eaten for 5 consecutive days.

Data from ClinicalTrials.gov

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