We aims to investigate the effects of prone positioning and nitric oxide inhalation in adult patients who is diagnosed with COVID-19 associated acute respiratory distress syndrome by electrical impedance tomography.
The investigators aim to investigate the effects of prone positioning and nitric oxide inhalation in adult patients who is diagnosed with COVID-19 associated acute respiratory distress syndrome by electrical impedance tomography (EIT). The EIT assessment is performed in patients ventilated in supine position, supine position with NO inhalation for 1 hour, prone position for 1 hour, prone position for 2 hours with NO inhalation for 1 hour, prone position for 3 hours, prone position for 16 hours, re-supine position for 3 hours. Arterial blood gas (ABG) analysis results, ventilator parameters and hemodynamic parameters are also recorded at each time point.
Study Type
OBSERVATIONAL
Enrollment
20
ventilation at prone positioning
NO inhalation at 20 ppm
Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, China
RECRUITINGoxygenation status
To evaluate the oxygenation parameters
Time frame: 1 day
regional distribution of pulmonary perfusion
To evaluate the effect of prone positon and NO inhalation on pulmonary blood flow distribution.
Time frame: 1 day
regional distribution of pulmonary ventilation
To evaluate the effect of prone positon and NO inhalation on pulmonary vetilation distribution.
Time frame: 1 day
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