Salivary Cystatin S Levels in a Group of Egyptian Children

N/AActive Not RecruitingNCT05716867

Cairo University30 enrolled

Overview

Aim of the study 1. Measuring the levels of salivary cystatin S protein and salivary buffering capacity to determine their relation to early childhood caries. 2. Predection of early childhood caries by using salivary cystatin S levels with demographic, clinical and nutrition habits characteristics of the participants.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Early Childhood Caries

Interventions

Measurement of salivary cystatin S protein levels in salivaBIOLOGICAL

The human cystatin S enzyme-linked immunosorbent assay (ELISA) kit will be used to measure the amounts of cystatin S in saliva for cases and controls

Eligibility

Sex: ALLMin age: 36 MonthsMax age: 71 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Medically free children aged 36 to 71 months with one or more decayed (noncavitated or cavitated lesions), missing, or filled teeth due to caries in any primary tooth(cases). * Medically free children aged 36 to 71 months with no decayed, missing, or filled teeth due to caries in any primary tooth(controls). Exclusion Criteria: * Children receiving antibiotic therapy within three month and fluoride prophylaxis within one year. * Parents who will refuse to participate or refuse to sign the informed consent. * Children who will not agree or cooperate with participation.

Locations (1)

Faculty of Oral and Dental Medicine Cairo University

Cairo, Egypt

Outcomes

Primary Outcomes

Levels of salivary cystatin S protein

Levels of salivary cystatin S protein measured by Human cystatin S enzyme linked immunosorbent assay (ELISA) kit (unit ng/ml)

Time frame: 2 months

Secondary Outcomes

Buffer Capacity

Buffer Capacity measured by PH meter

Time frame: 2 months

Demographic, clinical and nutrition habits characteristics of participants Interview

Demographic, clinical and nutrition habits characteristics of participants, using interview

Time frame: 2 months

Data from ClinicalTrials.gov

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