The goal of this interventional study is to learn about nasal microbiome and viral infections in newborns hospitalised in neonatology. The main questions it aims to answer are : * how often are newborns infected by viruses in neonatology ? * how does the microbiome develop during first weeks of life ? * how does microbiome and viruses interacts together ? * is there a link between viral infection, microbiome, and medical complications during hospitalisation in neonatology ? Participants will have a nasal swab taken each week during their hospitalisation in neonatology, and researchers will take medical data from the medical chart.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
38
We will take nasal swabs from anterior and middle nostril, once a week for each newborn included.
CAEN University Hospital
Caen, France
Change in microbiome diversity
Shannon diversity index
Time frame: Day 0, day 7, day 14, and each week until discharge (maximum duration : 3 months for each newborn).
Change in microbiome abundance
Number of reads for a given taxonomy.
Time frame: Day 0, day 7, day 14, and each week until discharge (maximum duration : 3 months for each newborn).
Virus presence
Molecular detection of respiratory viruses using multiplex PCR.
Time frame: Day 0, day 7, day 14, and each week until discharge (maximum duration : 3 months for each newborn).
Occurence of bronchopulmonary dysplasia
assessed by clinical recording on discharge from neonatology
Time frame: At discharge from neonatology.
Change in expression of local innate immunity markers
Mesure of the expression of the interferon-stimulated genes (ISGs), anti-viral genes, and the inflammasome pathway.
Time frame: Day 0, day 7, day 14, and each week until discharge (maximum duration : 3 months for each newborn).
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