Stereotactic Radiology Versus Chemotherapy for Recurrent/Progressive Glioblastoma After Second-Line Chemotherapy

Inclusion Criteria: * Histologically proven intracranial glioblastoma multiforme with pathologic or imaging confirmation of tumor progression or regrowth after failure of two previous treatment regimens * Initial low-grade glioma and a subsequent diagnosis of glioblastoma or gliosarcoma * History and physical exam, including neurologic examination, within 4 weeks prior to registration Exclusion Criteria: • Warfarin or LMW heparin patients must have no active bleeding or pathological condition that carries a high risk of bleeding