Familial B-cell Lymphoproliferative Disorders

N/ANot Yet RecruitingNCT05718986

University of Haifa1,000 enrolled

Overview

This study investigates families with at least two cases of B-cell lymphoproliferative disorders (LPD), and evaluates the prevalence of LPD in families, the relationship between medical history, genetic factors, and the risk of familial LPD, and various clinical outcomes for these families in a multiethnic population of Jews and Arabs in Israel.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Lymphoproliferative Disorders Premalignant Monoclonal B-Cell Lymphocytosis Chronic Lymphocytic Leukemia

Interventions

No interventionOTHER

No intervention

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patient inclusion criteria: Patients must have LPD and must have a family history of LPD. LPD patients who signed an informed consent to participate in the study. Criteria for the inclusion of relatives of patients: Relatives must be related by blood to LPD patients or unrelated (for control group). Relatives who signed an informed consent to participate in the study. Exclusion Criteria: * Pregnant women, special populations and those lacking judgment will not be included

Outcomes

Primary Outcomes

Prevalence of familial LPD in Israel

Time frame: 5 years

Association between medical history and genetic variants and the risk of familial LPD

Time frame: 5 years

Risk of clinical outcomes among familial LPD and family members

Time frame: 15 years

Central Contacts

Geffen Kleinstern, PhD

CONTACT

+972545715624 gkleinste@univ.haifa.ac.il

Tamar Tadmor, MD

CONTACT

tamar.tadmor@b-zion.org.il

Data from ClinicalTrials.gov

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