Efficacy, Tolerability and Safety of Intravenous D-VC With ATO in Patients With Advanced/Metastatic Colorectal Cancer

Phase 1: INCLUSION CRITERIA: * informed consent to participate in the study * patients of the second clinical group with malignant neoplasms of a common/metastatic form that have exhausted standard therapy. * patients who have received at least 3 lines of standard therapy, including those with the use of targeted drugs, patients who have exhausted the possibilities of using specialized drugs, as part of the recommendations of treatment protocols * the presence of "+" KRAS / NRAS status of the primary tumor or metastatic focus (determined in LEKzone 2, codons 12, 13, 61) * ≥1 measurable lesion defined by RECIST v1.1 * ECOG PS 0.1 or 2 EXCLUSION CRITERIA: * age up to 18 years * pregnancy and lactation * patients with an autoimmune disease or with a medical diagnosis requiring systemic immunosuppression * decompensated diabetes mellitus * renal failure, urolithiasis * diabetes * thrombophlebitis, tendency to thrombosis * severe lung disease, dyspnea at rest, pleural effusion * cardiovascular insufficiency, ejection fraction of the heart \<40% * sensory neuropathy of the 1st degree of any etiology * uncontrolled infections * persons from the category of "vulnerable patients" (homeless, military personnel, incapacitated, patients in emergency conditions, other persons who may be subjected to pressure); * Allergy in history and during screening (drug, pollen, etc.); * participation in any other clinical trial; * hypersensitivity to arsenic; * individual intolerance to ascorbic acid; * thrombophlebitis and thrombosis, a tendency to thrombosis in history; * increased blood clotting and pathologies associated with this deviation; * diabetes; * nephrolithiasis or nephrolithiasis; * the patient does not agree to perform the procedures required by the protocol and is unable to adhere to the schedule of procedures. * if the patients have any other laboratory or other abnormalities, in the opinion of the Investigator, that can harm the patients and the results of the study. Phase II: INCLUSION CRITERIA: for both groups (30 patients, considering 20% decrease from the study): * informed consent to participate in the study * patients of the second clinical group with advanced/metastatic colorectal cancer * Patients must have previously received at least 3 lines of standard drug therapy, including those with the use of targeted drugs, who have exhausted the possibilities of using specialized drugs, as part of the recommendations of colorectal cancer treatment protocols - the presence of "+" KRAS / NRAS status of the primary tumor, or metastatic focus (determined in exon 2, codons 12, 13, 61) * ≥1 measurable lesion defined by RECIST v1.1 * ECOG PS 0.1 or 2 EXCLUSION CRITERIA: * age up to 18 years * patients with an autoimmune disease or with a medical diagnosis requiring systemic immunosuppression * decompensated diabetes mellitus * renal failure, urolithiasis * thrombophlebitis, tendency to thrombosis * severe lung disease, dyspnea at rest, pleural effusion * cardiovascular insufficiency, ejection fraction of the heart \<40% * sensory neuropathy of the 1st degree of any etiology * uncontrolled infections * persons from the category of "vulnerable patients" (homeless, military personnel, incapacitated, patients in emergency conditions, other persons who may be subjected to pressure); * Allergy in history and during screening (drug, pollen, etc.); * participation in any other clinical trial; * hypersensitivity to arsenic; * individual intolerance to ascorbic acid; * thrombophlebitis and thrombosis, a tendency to thrombosis in history; * increased blood clotting and pathologies associated with this deviation; * diabetes; * nephrolithiasis or nephrolithiasis; * the patient does not agree to perform the procedures required by the protocol and is unable to adhere to the schedule of procedures. * if the patients have any other laboratory or other abnormalities, in the opinion of the Investigator, that can harm the patients and the results of the study.