This project focuses on the evaluation of the impact of the rapid mutltiplex test on changes in anti-infectious treatments in kidney transplant patients with diarrhea. A higher number of infectious agents detected on the same day of sampling could improve the etiological diagnosis of diarrhea in kidney transplant patients and optimize therapeutic management. A prospective study will be conducted to evaluate the impact of a rapid multiplex test with a wide panel of bacteria, viruses and parasites on the clinical management of kidney transplant patients with acute diarrhea. This impact will be evaluated using a control group of kidney transplant patients with acute diarrhea whose infectious diagnosis will be performed by standard methods. The main objective is to determine the impact of the rapid multiplex test on changes in anti-infectious treatments (initiation, change of molecule, total duration of treatment).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
135
Rapid multiplex Polymerase Chain Reaction (PCR) assay for digestive infectious agents in stool sample in the baseline diagnostic tests panel
Difference in the proportion of patients with anti-infectious treatment change
Difference in the proportion of patients with an adapation of anti-infectious treatment between the 2 randomized groups (rapid multiplex test group versus standard tests in patients with acute diarrhea)
Time frame: 1 week
Difference in the time to anti-infectious treatment change
Difference in the time to an adaptation of anti-infectious treatment between the 2 randomized groups (rapid multiplex test group versus standard tests in patients with acute diarrhea)
Time frame: 1 week
Difference in the proportion of patients with an adaptation of immunosuppressive therapy
Difference in the proportion of patients with an adaptation of immunosuppressive therapy between the 2 randomized groups (rapid multiplex test group versus standard tests in patients with acute diarrhea)
Time frame: 30 days
Difference in the time to adaptation of immunosuppressive therapy
Difference in the time to adaptation of immunosuppressive therapy between the 2 randomized groups (rapid multiplex test group versus standard tests in patients with acute diarrhea)
Time frame: 30 days
Proportion of patients with additional tests for the etiological diagnosis of diarrhea
Difference in the proportion of patients with additional tests for the etiological diagnosis of diarrhea between the 2 randomized groups (rapid multiplex test group versus standard tests in patients with acute diarrhea)
Time frame: 30 days
Number of additional tests for the etiological diagnosis of diarrhea
Difference in the number additional tests for the etiological diagnosis of diarrhea between the 2 randomized groups (rapid multiplex test group versus standard tests in patients with acute diarrhea)
Time frame: 30 days
Time to digestive endoscopy
Difference in the time to digestive endoscopy between the 2 randomized groups (rapid multiplex test group versus standard tests in patients with acute diarrhea)
Time frame: 30 days
Duration of diarrhea
Difference in the duration of diarrhea between the 2 randomized groups (rapid multiplex test group versus standard tests in patients with acute diarrhea)
Time frame: 30 days
Proportion of patients with asymptomatic carriage of infectious agents
Proportion of patients with asymptomatic carriage of infectious agents in the asymptomatic control group
Time frame: Day 1
Quantitative polymerase chain reaction (PCR) by multiplex PCR for infectious agents
Quantitative polymerase chain reaction (PCR) by multiplex PCR for infectious agents on a stool sample at baseline
Time frame: Day 1
Alpha-diversity
Microbiota alpha-diversity on a stool sample at baseline
Time frame: Day 1
Beta-diversity
Microbiota beta-diversity on a stool sample at baseline
Time frame: Day 1
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