The circulation of the Hepatitis D Virus (HDV) has considerably diminished in Italy, secondary to the control of the Hepatitis B Virus (HBV) with vaccination; this has led to the perception that HDV is vanishing and has reduced attention to the diagnosis of Hepatitis D. However, migratory fluxes from HDV endemic areas, fostered by labour-forces globalization, are increasingly reconstituting the reservoir of HDV in the country and hepatitis D has not yet vanished in native Italians but will remain an important medical issue for several years to come. As the epidemiologic and clinical features of HDV infection in migrant communities are largely unknown and the features of native Italians with long standing HDV infections have not been updated, this project intends to establish the contemporary epidemiological and medical context of HDV in immigrants in Italy and to determine the clinical characteristics and needs of the residual cohort of native HDV Italians, through the analysis of all HDV cases recruited in 12 months in a coordinated network of 35 Italian medical centers. The data will provide an appraisal of the burden of hepatitis D in the country and of its impact on the National Health System. They will present the paradigm of the current trend of HDV infection in high-income countries in the world.
Study Type
OBSERVATIONAL
Enrollment
515
Università degli Studi di Bari Aldo Moro
Bari, Italy
Gastroenterology Hepatology and Transplantation, ASST Bergamo
Bergamo, Italy
Malattie Infettive, ASST Bergamo
Bergamo, Italy
Dipartimento di Scienze Mediche e Chirurgiche, Università degli Studi di Bologna
Bologna, Italy
Dipartimento di Scienze Cliniche e Sperimentali, Università degli Studi di Brescia
Brescia, Italy
UOC Malattie Infettive e Tropicali, A.O. S Anna e S Sebastiano
Caserta, Italy
UOS Epatologia "G. Rodolico-San Marco"
Catania, Italy
UOC Medicina Interna Ospedaliera, Policlinico "Mater Domini"
Catanzaro, Italy
Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Foggia
Foggia, Italy
S.C. Malattie Infettive, E.O. Ospedali Galliera
Genova, Italy
...and 26 more locations
Demographic characteristics of HDV-infected patients
Demographic characteristics: age, sex, height, weight, nationality. HDV means hepatitis D virus
Time frame: 1 year
Epidemiologic characteristics of HDV-infected patients
Risk factors for infection. HDV means hepatitis D virus
Time frame: 1 year
Serum alanine aminotransferase concentration values in HDV-infected patients
HDV means hepatitis D virus
Time frame: 1 year
Blood platelet count in HDV-infected patients
HDV means hepatitis D virus
Time frame: 1 year
Serum albumin concentration values in HDV-infected patients
HDV means hepatitis D virus
Time frame: 1 year
Serum total bilirubin concentration values in HDV-infected patients
HDV means hepatitis D virus
Time frame: 1 year
Serum anti-liver-kidney microsomal antibodies titer in HDV-infected patients
HDV means hepatitis D virus
Time frame: 1 year
Proportion of patients with detectable HDV RNA among seropositive anti-HDV patients
HDV means hepatitis D virus
Time frame: 1 year
Serum HDV RNA levels in HDV-infected patients
HDV means hepatitis D virus
Time frame: 1 year
Proportion of HDV genotypes among patients with detectable HDV RNA
HDV means hepatitis D virus
Time frame: 1 year
Proportion of patients with detectable HBV DNA among seropositive anti-HDV
HBV means hepatitis B virus. HDV means hepatitis D virus
Time frame: 1 year
Serum HBV DNA levels in HDV-infected patients
HBV means hepatitis B virus. HDV means hepatitis D virus
Time frame: 1 year
Proportion of HBV genotypes among patients with detectable HBV DNA
HBV means hepatitis B virus
Time frame: 1 year
HBsAg concentration levels in HDV-infected patients
HBsAg means hepatitis B surface antigen. HDV means hepatitis D virus
Time frame: 1 year
HBcrAg concentration levels in HDV-infected patients
HBcrAg means hepatitis B core-related antigen. HDV means hepatitis D virus
Time frame: 1 year
Proportion of patients with liver cirrhosis among seropositive anti-HDV
HDV means hepatitis D virus
Time frame: 1 year
Liver stiffness values in HDV-infected patients
HDV means hepatitis D virus
Time frame: 1 year
Proportion of patients with hepatocellular carcinoma among seropositive anti-HDV
HDV means hepatitis D virus
Time frame: 1 year
Proportion of patients treated with antiviral therapy among seropositive anti-HDV
HDV means hepatitis D virus
Time frame: 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.