Study of Nasal Mucosa Histopathological Changes in Chronic Hypersensitivity Pneumonitis

Cairo University40 enrolled

Overview

Background:Hypersensitivity pneumonitis (HP) is an interstitial lung disease that develops after inhalation of organic or inorganic antigens in susceptible individuals. The nasal mucosa is constantly exposed to these antigens that can irritate the respiratory mucosa. Objectives: to assess the burden of sinonasal symptoms in HP patients and to evaluate the nasal histopathology in those patients.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Hypersensitivity Pneumonitis Nasal Mucosal Disorder

Interventions

nasal endoscopyPROCEDURE

nasal endoscopy and mucosal biopsy

Eligibility

Sex: ALLMin age: 29 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * all patients with clinical and radiological features of HP Exclusion Criteria: * respiratory failure * patients on anticoagulants

Locations (1)

Kasr alainy school of medicine

Cairo, Egypt

Outcomes

Primary Outcomes

percentage of patients with HP developed nasal mucosa granuloma and lymphocytic infiltrations as detected by nasal endoscopy

nasal endoscopy and nasal mucosa biopsy was done for all patients to measure the % of patients with nasal granuloma and lymphocytic infiltrations

Time frame: 6 months

Data from ClinicalTrials.gov

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