The MRI perfusion imaging using arterial spin labeling (ASL)'s non-invasive technique (i.e. without injection of contrast medium) allows, thanks to recent technological improvement of the spatial resolution, measuring several perfusion parameter of the retinal tissue such as the regional Blood Flow (rBF) or the cerebral blood flow (cBF) expressed in ml/100g/min. Reliable application of ASL thus requires the precision and specificity of the MRI protocol to be tested.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
70
Patients will undergo through an MRI-scan using the ASL MRI sequence, as described per protocol.
Cliniques Universitaires Saint Luc
Brussels, Brussels Capital, Belgium
RECRUITINGRepeatability measurement on volunteers
implementing a protocol based on 2 imaging sessions : 1st session with 2 ASL sequences and a 2nd session scheduled 5-7 days later in similar conditions including 1 ASL in volunteers will be applied. This protocol allows assessing the intra-day and the inter-day variability of the measurements using Intra-Class Correlation Coefficient and metric derived from Bland-Altman plots. A total of 20 MRI examinations are planned for this phase of the study.
Time frame: 2 month
Mesurement of the retinal perfusion by MRI ASL in patient in acute phase
Analysing the retinal perfusion by ASL to be able to figure out if the decreased visual acuity has an ischemic etiology.
Time frame: 4 years
Mesurement of the retinal perfusion by MRI ASLin patient in a chronic phase
Following up the disease process (stability, progression or reversal of the decrease in visual acuity).
Time frame: 4 years
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