Intubation Conditions After RSI Using Rocuronium with Ephedrine Pretreatment

Ain Shams University75 enrolled

Overview

This trial will study if ephedrine pretreatment before low doses of rocuronium (0.6 or 0.8 mg/kg) would provide similar intubating conditions as with the high dose of 1.2 mg/kg in patients undergoing RSII.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

SINGLE

Enrollment

Conditions

Rapid Sequence Induction and Intubation

Interventions

EphedrineDRUG

70 μg/kg as pretreatment

Rocuronium 0.6DRUG

0.6 mg/kg

Rocuronium 0.8DRUG

0.8 mg/kg

Rocuronium 1.2

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA physical status I or II Exclusion Criteria: * Neuromuscular disease: myopathies * On drugs that interact with the neuromuscular junction or ephedrine * Cardiovascular disease: hypertension or ischemic heart disease * Increased risk of pulmonary aspiration: * GERD * Pregnancy * Anticipated airway difficulties: * Mallampati grade III or IV * Obesity (BMI ≥30 kg/m2), * Hypersensitivity to any of the study drugs

Locations (1)

Ain Shams University Hospitals

Cairo, Egypt

Outcomes

Primary Outcomes

Intubation conditions

Evaluation of intubation conditions after rapid sequence induction using rocuronium 0.6 or 0.8 mg/kg with ephedrine pretreatment, compared with 1.2 mg/kg, according to the criteria of the Good Clinical Research Practice (GCRP) in pharmacodynamic studies of NMBAs (Fuchs-Buder et al., 2007), which assess each of the following variables for their qualities described as: (excellent, good, poor) * ease of laryngoscopy (easy, fair, difficult) * vocal cords position (abducted, intermediate, closed) * reaction to tracheal tube insertion and cuff inflation (coughing: none, slight, vigorous) The 3 variables will be combined to describe intubation conditions as: * Excellent: if all qualities are excellent * Good: if all qualities are either excellent or good * Poor: if there is a single poor quality

Time frame: after 60 seconds of rocuronium administration

Secondary Outcomes

Heart rate

Following up the heart rate on the monitor

Time frame: every minute of the first 5 minutes of intubation

Mean arterial pressure

Following up the mean arterial pressure by noninvasive blood pressure monitoring

Time frame: every minute of the first 5 minutes of intubation

Data from ClinicalTrials.gov

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