The goal of this subproject is to examine the hypothesized improvement of treatment with chess-based training and sleep enhancement, both together and on their own, in smokers. Participants will undergo fMRI measurements, sleep monitoring. They will then be assigned to one of the four experimental groups, including high-intensity interval training with or without chess-based training.
This subproject aims to improve treatment outcome in patients with tobacco use disorder (TUD) by enhancing cognitive control. Evidence from the first funding period (1st FP) indicates that enhancing cognitive control using cognitive remediation training (CRT, in our case chess-based) can improve outcomes of a standard smoking cessation program. The current project will harness three means to build on this success of enhancing cognitive control by: 1. using our tried-and-tested chess-based training, 2. improving sleep using high-intensity interval training (HIIT), 3. increasing sleep-dependent consolidation of the chess-based training (see Figure 1). We hypothesize that chess-based training and sleep enhance treatment outcome, both together and on their own. To test our hypotheses, we will combine smoking cessation treatment with the aforementioned approaches as app-based add-ons (chess-based training and HIIT). This will not only allow us to apply the training in a cost-efficient way out-side the lab, it may also increase patients' compliance.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
140
Each subject will receive a standard SCP as group treatment once a week (1h) over six weeks. This group therapy is based on behavioural therapy and a psycho-educational approach (for more details see Batra \& Buchkremer, 2004), and will be carried out by a qualified therapist.
The cognitive remediation treatment (CRT) employs a chess-based battery of tasks (delivered through an app-based online tool), two times per week over six weeks (60min duration per session).
The high-intensity interval training will be delivered through an app environment with several choices of exercise, two times per week over six weeks. The training will include a 5-minutes warm-up and cool down phase. In between, participants will perform four 4-minutes blocks of exercise at high intensity, interspersed with three 3-minute blocks of low intensity (total of 35 minutes exercise).
Klinik für Abhängiges Verhalten, Zentralinstitut für Seelische Gesundheit
Mannheim, Baden-Wurttemberg, Germany
RECRUITINGTime until first severe relapse
days until the first severe smoking relapse after treatment
Time frame: timepoint 3: follow-up 3 months after end of SCP
Percentage of abstinent days
Percentage of abstinent days in the 3 months after treatment
Time frame: timepoint 3: follow-up 3 months after end of SCP
Change in smoking urges
questionnaire of smoking urges (QSU, Müller et al. 2001)
Time frame: 2 time points: before and after 6 weeks SCP
Change in neural measures of response inhibition
SST fMRI task (Gan et al., 2014)
Time frame: 2 time points: before and after 6 weeks SCP
Change in neural measures of working memory
Nback fMRI task (Charlet et al., 2014)
Time frame: 2 time points: before and after 6 weeks SCP
Change in neural functional connectivity in the salience network
resting state connectivity to seed region right anterior insula
Time frame: 2 time points: before and after 6 weeks SCP
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