The primary aim of this work is to evaluate the role of high frequency oscillatory ventilation (HFOV) in recruitment of lung in preterm newborns 32 to 37 weeks gestational age with moderate to severe respiratory distress. The secondary aim is to evaluate the role of chest ultrasound in monitoring of lung recruitment in comparison to routine chest x ray in those babies. Also cardiac hemodynamics will be assesed using functional echocardiography.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
72
establishment of lung recruitment using high frequency ventilation and assessment with chest ultrasound and echocardiography
Marwa Mohamed Farag
Alexandria, Egypt
RECRUITINGNeonatal Intensive Care Unit (NICU) of Alexandria University Maternity Hospital.
Alexandria, Egypt
NOT_YET_RECRUITINGchest US
A mobile device (PHILIPS ® HD11 XE) with a 10-MHz linear probe will be used for chest ultrasound the 12 lung zones will be assessed regarding 1. presence Of A lines, B-lines or C-profile 2. presence or absence of pleural sliding
Time frame: first 3 days after birth
Superior Vena Cava flow in ml/kg/min
Superior Vena Cava (SVC) Blood Flow using functional echocardiography
Time frame: first 3 days of life
estimated pulmonary artery pressure in mmHg
Pulmonary artery pressure (PAP) will be assessed by measuring tricuspid valve regurgitation peak velocity: this will be measured in apical 4 chamber view, with continous wave Doppler using modified Bernoulli equation. Systolic pulmonary artery pressure is equivalent to right ventricular systolic pressure in absence of outflow obstruction. Systolic Pulmonary Artery Pressure (SPAP) = Right Ventricular Systolic Pressure = 4x TR2 + Right Atrial Pressure (RAP), with RAP= 3-5 mmHg.
Time frame: first 3 days of life
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