Daily Single Shot Adductor Canal Block Versus Continuous Adductor Canal Block After Total Knee Arthroplasty

Seoul National University Hospital80 enrolled

Overview

This study will compare the analgesic efficacy of daily single-shot adductor canal block(ABC) versus continuous ACB after total knee arthroplasty (TKA).

Patients 19-75 years old, of ASA classification I-III scheduled for unilateral TKA, will be enrolled and randomized into two groups, single-shot ACB group and continuous ACB group. In both groups, participants will be administered a single-shot ACB immediately after the end of the operation. The single-shot ACB group will receive two separate single-shot ACBs, on the first and second postoperative day. A nerve block catheter will be placed in patients in the continuous ACB group, which will be connected to a patient-controlled analgesia pump until the second postoperative day. The primary outcome of this study is the average NRS pain score at rest from the end of surgery to 2 days after surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Postoperative Pain

Interventions

Single shot adductor canal blockPROCEDURE

Single shot adductor canal block on the the first and second postoperative day.

Continuous adductor canal blockPROCEDURE

A catheter will be placed in the adductor canal and connected to a continuous patient-controlled analgesia pump.

Eligibility

Sex: ALLMin age: 19 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ASA classification I, II, III * Patients scheduled for unilateral knee arthroplasty Exclusion Criteria: * Anesthesia other than spinal anesthesia * Chronic opioid use * Uncontrolled diabetes of HbA1c\>7.5 * Neuromuscular pathology of the ipsilateral leg * Second-look knee arthroplasty * Inability to communicate (e.g. dementia) * Hypersensitivity to ropivacaine * BMI \> 40 * Pregnancy

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Average NRS pain score at rest

average of numerical rating scale (0: no pain, 10: worst imaginable pain) pain scores from 8 time points during 48h (+4h, +8h, +12h from end of surgery, 6AM, 2PM, 10PM of postoperative day 1, and 6AM and 2PM of postoperative day 2)

Time frame: first 48h after end of surgery

Secondary Outcomes

numerical rating scale (0: no pain, 10: worst imaginable pain) pain score at rest at +4h from end of surgery

Time frame: +4h from end of surgery

numerical rating scale (0: no pain, 10: worst imaginable pain) pain score during movement at +4h from end of surgery

Time frame: +4h from end of surgery

NRS pain score at rest at +8h from end of surgery

Time frame: +8h from end of surgery

numerical rating scale (0: no pain, 10: worst imaginable pain) pain score during movement at +8h from end of surgery

Time frame: +8h from end of surgery

numerical rating scale (0: no pain, 10: worst imaginable pain) pain score at rest at +12h from end of surgery

Time frame: +12h from end of surgery

numerical rating scale (0: no pain, 10: worst imaginable pain) pain score during movement at +12h from end of surgery

Time frame: +12h from end of surgery

numerical rating scale (0: no pain, 10: worst imaginable pain) pain score at rest at 6AM on postoperative day 1

Time frame: 6AM on postoperative day 1

numerical rating scale (0: no pain, 10: worst imaginable pain) pain score during movement at 6AM on postoperative day 1

Data from ClinicalTrials.gov

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