The goal of this observational study is to learn about dynamic changes of Torquetenovirus (TTV) load in Chinese renal transplant recipients. The main questions it aims to answer are: * Is there correlation between TTV load and rejection? * Is there correlation between TTV load and infection? * Can changes in the TTV load of kidney transplant recipients predict rejection or infection? Participants will: * receive 13 follow-up visits within 1 year after kidney transplantation * provide 2 ml of whole blood for TTV load testing and other related testing at each follow-up * provide 10 ml of whole blood for dd-cfDNA testing at four follow-ups (1, 3, 6 and 12 months after transplantation) * provide 1 ml of serum for donor-specific antibody testing at three follow-ups (1, 6 and 12 months after transplantation)
Study Type
OBSERVATIONAL
Enrollment
220
West China Hospital,Sichuan University
Chengdu, China
RECRUITINGThe First Affiliated Hospital of Zhejiang University
Hangzhou, China
RECRUITINGChanghai Hospital affiliated to Naval Military Medical University
Shanghai, China
RECRUITINGTongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
Wuhan, China
RECRUITINGthe First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
RECRUITINGRenal allograft biopsy and serum creatinine
Any biopsy-proven acute rejection (Banff criterea) and clinical diagnosed acute rejection
Time frame: From day0 to day365 after kidney transplantation
Infection event
Any bacterial, fungal (including PJP), mycobacterial, or viral (including CMV viremia, EB viremia, BK Viremia, BK Viruria, etc.) infection requiring hospitalization or prolongation of hospitalization, or requiring intravenous antibiotics or therapeutic use of antiviral drugs, or requiring reduction of immunosuppressive drugs
Time frame: From day0 to day365 after kidney transplantation
donor-specific antibodies (DSA)
the development of de novo DSA or a 30% increase of MFI value in preformed DSA
Time frame: From day0 to day365 after kidney transplantation
donor derived cell-free DNA
An increase in absolute or percent donor derived-cell free DNA from 1 month post-transplant
Time frame: From day0 to day365 after kidney transplantation
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