Associations of Fecal Bile Acid Profile and Intestinal Flora With Chronic Radiation Enteritis

Inclusion Criteria: 1. . non-surgical cervical cancer patients aged 18 to 75 years who received radiotherapy; 2. . Patients who can fully understand the content of informed consent for this trial and voluntarily sign the written informed consent; 3. . able to receive follow-up examinations, follow-up examinations, and specimen retention on time; 4. . The case group met the diagnostic criteria for chronic radiation enteritis in the "Expert Consensus on the Diagnosis and Treatment of Radiation Proctitis in China (2018 edition)"; Control group 1: Non-surgical cervical cancer patients without chronic radiation enteritis after radiotherapy; Control group 2: Patients with cervical cancer who did not receive any treatment. Exclusion Criteria; 1. . Presence of diseases affecting bile acid metabolism, such as hepatitis and cirrhosis of the liver from various causes, gallstones, etc; 2. . Patients who have previously undergone cholecystectomy or partial resection of the intestine; 3. . Taking drugs affecting bile acid metabolism due to other diseases, such as cholestyramine, anti-inflammatory and Xiaoyan lidan tablets, Danshu capsules, ursodeoxycholic acid, obeticholic acid, and proprietary Chinese medicines such as schisandrin B, Tanshinone IIA, and Yinjiazhuang; 4. . Recent use of drugs that affect gastrointestinal motility; 5. . Patients with moderate or severe renal impairment (blood creatinine \> 2 mg/dL or 177 mmol/L), or abnormal liver function (ALT \> 2 times the upper limit of normal value); moderate or severe chronic obstructive pulmonary disease; patients with severe hypertension, patients with cerebrovascular accidents; patients with congestive heart failure, unstable angina pectoris; 6. . Patients with mental or legal disabilities; 7. . Suspected or confirmed history of alcohol/substance abuse or other pathology that, in the judgment of the investigator, reduces the likelihood of enrollment or complicates enrollment; 8. . Refuse to sign informed consent;