Cannabis and Opioid Use Disorder

Phase 1RecruitingNCT05729932

University of Kentucky15 enrolled

Overview

This study plans to enroll participants with opioid use disorder who are not currently seeking treatment to assess the effects of cannabis on opioid withdrawal and other related outcomes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Opioid Use Disorder

Interventions

Inhaled vaporized cannabisDRUG

Double-blind cannabis and placebo doses, administered through vaporizer

Intransal opioidDRUG

Double-blind opioid and placebo doses, administered intranasal route

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Current opioid use disorder Exclusion Criteria: * Current medical conditions that require medical management

Locations (1)

Center on Drug and Alcohol Research

Lexington, Kentucky, United States

RECRUITING

Outcomes

Primary Outcomes

Change from Baseline - Opioid Withdrawal Severity - Visual Analog Scale (VAS)

Subjective ratings of opioid withdrawal severity on visual analog scale (scale 0-100; 0 = not at all, 100 = extremely)

Time frame: Change from baseline

Secondary Outcomes

Change from Baseline - Opioid Drug Liking - Visual Analog Scale (VAS)

Subjective ratings of drug liking on visual analog scale (scale 0-100, 0 = not at all, 100 = extremely)

Time frame: Change from baseline

Change from Baseline - Respiration

Physiological monitoring of respiration rate (breaths per minute)

Time frame: Change from baseline

Central Contacts

Paul Nuzzo, MA

CONTACT

859-323-0002 pnuzz2@email.uky.edu

Data from ClinicalTrials.gov

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