Histological Assessment of BMAC Utilized in Sinus Lift

Cairo University12 enrolled

Overview

Aim : The aim of present study was to evaluate BMAC/bovine graft utilization in Sinus membrane augmentation on bone quality and quantity. Methodology: sixteen patients suffering from atrophic posterior maxilla with sinus pneumatization were randomly divided into two equal groups: study group: the sinus membrane was elevated with BMAC/bovine graft whereas the control group recieved bovine graft only for sinus floor augmentation. All patients will be evaluated at 1 week, 4 months to measure bone height and bone core biopsy for histological assessment at 4 months during implant placement.

Aim : The aim of present study was to evaluate BMAC/bovine graft utilization in Sinus membrane augmentation on bone height gain and quality of bone on histological assessment. Methodology: sixteen patients suffering from atrophic posterior maxilla with sinus pneumatization were randomly divided into two equal groups: study group: the sinus membrane was elevated with bone marrow aspirate concentrate loaded on bovine graft whereas the control group recieved bovine graft only for sinus floor augmentation. All patients will be evaluated at 1 week, 4 months by CBCT to measure bone height and bone core biopsy for histological assessment at 4 months during implant placement.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Implant Site Reaction

Interventions

BMAC loaded on bovine graftDRUG

Bone marrow aspirate concentrate loaded on bovine graft for sinus floor augmentation

Bovine graft onlyDRUG

Bovine graft only for sinus floor augmentation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with missing upper posterior teeth and atrophic posterior maxilla with a residual bone height ranging from 4 to 6 mm * Patients who has as deficient as 4 mm vertical bone height in posterior maxilla that need bone augmentation before delayed implant placement. * Highly motivated patients Exclusion Criteria: * Patients suffering from any systemic disease or those under any medication that may interfere with normal bone healing. * Patients suffering from any sinus pathosis. * Patients with conditions that could potentially compromise BM quality, previous BMA, or acute illness. * Heavy smoker (\> 20 cigarettes daily)

Locations (1)

Faculty of Dentistry, department of oral and Maxillofacial Surgery

Cairo, Egypt

Outcomes

Primary Outcomes

Histological assessment

Histological assessment of core biopsy obtained at time of implant placement for percentage of new bone formation and residual graft

Time frame: After 4 months of surgery

Secondary Outcomes

Implant stability

implant stability immediately following installation after 4 months using ostell device (ISQ scale)

Time frame: After 4 months of surgery

Bone gain

Vertical bone height gain from sinus floor on cone beam ct

Time frame: Preoperative, immediate and 4 months Postoperative

Data from ClinicalTrials.gov

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