Diagnostic Accuracy of lncRNA DQ786243 and miRNA146a in Saliva of Oral Potentially Malignant Lesions

Fayoum University45 enrolled

Overview

The aim of this study is to evaluate salivary expression of lncRNA DQ786243 as a potential marker for diagnosis of oral potentially malignant lesions compared to normal controls and its effect on salivary expression of miRNA146a.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Potentially Malignant Lesions Oral Lichen Planus Leukoplakia, Oral

Interventions

Real-time Polymerase Chain Reaction techniqueDIAGNOSTIC_TEST

Real-time Polymerase Chain Reaction technique

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * participants will be divided into 3 groups: Group I: patients suffering from oral lichen planus Group II: patients suffering from leukoplakia Group III: healthy subjects who are systemically free, non-smokers, and not suffering from any oral mucosal lesions. Exclusion Criteria: * Subjects taking any drugs inducing any changes that could affect the salivary flow. * Pregnant females. * Subjects have any allergies, infectious diseases or active dental abscesses during one month before saliva sampling. * Patients receiving any drugs related to the oral lesions in the past 6 month prior to sample collection.

Locations (1)

Fayoum University

Al Fayyum, Egypt

Outcomes

Primary Outcomes

salivary expression of lncDQ786243 in OLP, Leukoplakia, control

Time frame: 2 months

Secondary Outcomes

salivary expression of miRNA146a in OLP, Leukoplakia, control

Time frame: 2 months

Data from ClinicalTrials.gov

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